I-Ching WangPersonal data of - College of Life Science, National Tsing Hua University

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Name	I-Ching Wang
Office Tel.	03-5742003
Office	Room 530,LS Bldg. II
E-mail

Category	Full-Time
Title	Associate Professor
單位別	Institute of Biotechnology / The Department of Life Sciences / Interdisciplinary Program of Life Science
Discipline	Gene transcriptional regulation / Cancer Biology / Lung Development and Carcinogenesis
Research expertise	Transcriptional regulation in lung development and carcinogenesis

Recent Publications
Year	Publication	Author
2019	Kurahashi T, Yoshida Y, Ogura S, Egawa M, Furuta K, Hikita H, Kodama T, Sakamori R, Kiso S, Kamada Y, Wang IC, Eguchi H, Morii E, Doki Y, Mori M, Kalinichenko VV, Tatsumi T, Takehara T.,2019,Forkhead Box M1 transcription factor drives liver inflammation linking to hepatocarcinogenesis in mice.,Cell Mol Gastroenterol Hepatol,9,3,pp425-446 (SCI)	I-Ching Wang
2019	Hsieh NT, Huang CY, Li CC, Wang IC, Lee MF,2019,MED28 and forkhead box M1 （FOXM1） mediate matrix metalloproteinase 2 （MMP2）-dependent cellular migration in human nonsmall cell lung cancer （NSCLC） cells,Journal of Cellular Physiology,234,7,pp11265-11275 (SCI)	I-Ching Wang
2017	Sun L, Ren X, Wang IC, Pradhan A, Zhang Y, Flood HM, Han B, Whitsett JA, Kalin TV, Kalinichenko VV,2017,The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice,Sci Signal,10,475,ppeaai8583- (SCI)	I-Ching Wang
2014	Wang IC, Ustiyan V, Zhang Y, Cai Y, Kalin TV, Kalinichenko VV.,2014,Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic KrasG12D,Oncogene,33,46,pp5391-5396 (SCI)	I-Ching Wang
2013	Balli D, Ustiyan V, Zhang Y, Wang IC, Masino AJ, Ren X, Whitsett JA, Kalinichenko VV, Kalin TV.,2013,Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition,EMBO J,32,2,pp231-44 (SCI)	I-Ching Wang
2012	Ustiyan V, Wert SE, Ikegami M, Wang IC, Kalin TV, Whitsett JA, Kalinichenko VV.,2012,Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways,Developmental Biology ,370,2,pp198-212 (SCI)	I-Ching Wang
2012	I-Ching Wang, Jonathan Snyder, Yufang Zhang, Julie Lander, Yuto Nakafuku, James Lin, Gang Chen, Tanya V. Kalin, Jeffrey A. Whitsett and Vladimir V. Kalinichenko,2012,Foxm1 Mediates a Cross-talk between Kras/MAPK and Canonical Wnt Pathways during Development of Respiratory Epithelium.,MCB,32,19,pp3838-50 (SCI)	I-Ching Wang
2011	Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV. ,2011,expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development., PLoS One,6,7,ppe22217- (SCI)	I-Ching Wang
2010	Wang IC, Zhang Y, Snyder J, Sutherland M, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV. ,2010,Increased expression of Foxm1 Transcription Factor in Respiratory Epithelium Inhibits Lung Sacculation and Causes Clara Cell Hyperplasia. ,Dev. Biol.,347,2,pp301-314 (SCI)	I-Ching Wang
2009	Ustiyan V, Wang IC, Ren X, Zhang Y, Snyder J, Xu Y, Wert SE, Lessard JL, Kalin TV, Kalinichenko VV. ,2009,Forkhead Box M1 transcription factor is required for smooth muscle cell during embryonic development of blood vessels and esophagus. ,Dev. Biol. ,336,2,pp266-279 (SCI)	I-Ching Wang
2009	Wang IC, Meliton L, Ren X, Zhang Y, Balli D, Snyder J, Whitsett JA, Kalinichenoko VV, Kalin TV.,2009,Deletion of FoxM1 Transcription Factor from Lung Epithelial Cells Inhibits Pulmonary Tumorigenesis.,PLoS One,4,8,ppe6609- (SCI)	I-Ching Wang
2008	Kalin TV, Wang IC, Meliton L, Zhang Y, Wert SE, Ren X, Snyder J, Bell SM, Graf L Jr, Whitsett JA, Kalinichenko VV. ,2008,Forkhead Box m1 transcription factor is required for perinatal lung function., Proc. Natl. Acad. Sci. USA,105,49,pp19329-19334 (SCI)	I-Ching Wang
2008	Wang IC, Chen YJ, Hughes DE, Ackerson T, Major ML, Costa RH, Tyner AL, Raychaudhuri P and Lau LF. ,2008,FOXM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness., J. of Biol. Chem.,283,30,pp20770-8 (SCI)	I-Ching Wang
2008	Wang IC, Meliton L, Ramakrishna S, Tretiakova M, Kalinichenko VV and Kalin TV. ,2008,The Forkhead BoxM1 Transcription Factor Accelerates Formation of Lung Tumors and Directly Induces Cox-2 Expression., Oncogene,27,30,pp4137-49 (SCI)	I-Ching Wang
2007	Yoshida Y, Wang IC, Yoder HM, Davidson NO and Costa RH. ,2007,The Forkhead Box M1 Transcription Factor is Required for Development and Growth of Mouse Colorectal Cancer. ,Gastroenterology,132,4,pp1420-31 (SCI)	I-Ching Wang
2007	Ramakrishna S, Kim IM, Petrovic V, Malin D, Wang IC, Kalin TV, Meliton L, Zhao YY, Qin Y, Malik AB, Costa RH, and Kalinichenko VV. ,2007,Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box m1 transcription factor.,Dev Dyn.,236,4,pp1000-1013 (SCI)	I-Ching Wang
2007	Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Ackerson T, Petrovic V, and Costa RH.,2007,A Cell Penetrating ARF Peptide Inhibitor of the Foxm1 Transcription Factor Is an Effective Treatment for Hepatocellular Carcinoma In Vivo. ,J Clin Invest.,117,1,pp99-111 (SCI)	I-Ching Wang
2006	Radhakrishnan SK, Bhat UG, Hughes DE, Wang IC, Costa RH and Gartel AL. ,2006,Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1.,Cancer Res. ,66,19,pp9731-9735 (SCI)	I-Ching Wang
2006	Zhao YY, Gao X, Vogel S, Kalinichenko VV, Wang IC, Costa RH, and Malik AB.,2006,Endothelial Proliferation and Vascular Re-annealing Following Injury Induced by LPS. ,J Clin Invest.,116,9,pp2333-43 (SCI)	I-Ching Wang
2006	Kim IM, Ackerson T ,Ramakrishna S, Tretiakova M, Wang IC, Gusarova GA, Yoder HM, Costa RH, and Kalinichenko VV. ,2006,The Forkhead Box m1 Transcription Factor Is Essential for Proliferation of Tumor Cells during Development of Lung Cancer. ,Cancer Res.,66,4,pp2153-2161	I-Ching Wang
2006	Kalin TV, Wang IC, Ackerson T, Major ML, Detrisac C, Kalinichenko VV, Lyubimov A and Costa RH. ,2006,Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Proliferation of Prostate Adenocarcinomas in both TRAMP and LADY Transgenic Mice. ,Cancer Res.,66,3,pp1712-1720 (SCI)	I-Ching Wang
2005	Wang IC, Chen YJ, Hughes DE, Petrovic V, Major ML, Park HJ, Tan Y, Ackerson T, and Costa RH.,2005,Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase. ,Mol Cell Biol. ,25,24,pp10875-94 (SCI)	I-Ching Wang
2005	Costa RH, Kalinichenko VV, Tan Y, and Wang IC.,2005,The CAR Nuclear Receptor and Hepatocyte Proliferation. ,Hepatology,42,5,pp1004-1008 (SCI)	I-Ching Wang
2004	Krupczak-Hollis K, Wang X, Kalinichenko VV, Gusarova GA, Wang IC, Dennewitz MB, Yoder HM, Kiyokawa H, Kaestner KH, Costa RH. ,2004,The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. ,Dev Biol.,276,1,pp74-88 (SCI)	I-Ching Wang
2003	Kalinichenko VV, Gusarova GA, Tan Y, Wang IC, Major ML, Wang X, Yoder HM, Costa RH. ,2003,Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury. ,J Biol Chem.,278,39,pp37888-94 (SCI)	I-Ching Wang
2003	Chuang SM, Wang IC, Hwua YS, Yang JL.,2003,Short-term depletion of catalase suppresses cadmium-elicited c-Jun N-terminal kinase activation and apoptosis: role of protein phosphatases.,Carcinogenesis,24,1,pp7-15 (SCI)	I-Ching Wang
2000	Chuang SM, Wang IC, Yang JL.,2000,Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium.,Carcinogenesis,21,7,pp1423-32 (SCI)	I-Ching Wang

Seminar paper summary
Year	Conference period	Publication	Author
2018	2018/04/21 2018/04/25	2018,2018/04/21-2018/04/25 (其他)	I-Ching Wang
2018	2018/04/21 2018/04/25	2018,2018/04/21-2018/04/25 (其他)	I-Ching Wang
2018	2018/03/24 2018/03/25	2018,2018/03/24-2018/03/25 (其他)	I-Ching Wang
2018	2018/03/24 2018/03/25	2018,2018/03/24-2018/03/25	I-Ching Wang
2017	2017/09/24 2017/09/27	2017,2017/09/24-2017/09/27 (其他)	I-Ching Wang
2017	2017/08/14 2017/08/14	2017,2017/08/14	I-Ching Wang
2016	2016/08/20 2016/08/20	2016,2016/08/20	I-Ching Wang
2016	2016/08/16 2016/08/16	2016,2016/08/16	I-Ching Wang
2016	2016/07/31 2016/08/05	2016,2016/07/31-2016/08/05 (其他)	I-Ching Wang
2016	2016/07/10 2016/07/15	2016,2016/07/10-2016/07/15 (其他)	I-Ching Wang
2016	2016/05/26 2016/05/26	2016,2016/05/26 (其他)	I-Ching Wang
2016	2016/05/26 2016/05/26	2016,2016/05/26 (其他)	I-Ching Wang
2016	2016/01/27 2016/01/29	2016,2016/01/27-2016/01/29 (其他)	I-Ching Wang
2015	2015/11/30 2015/11/30	2015,2015/11/30 (其他)	I-Ching Wang
2015	2015/11/05 2015/11/09	2015,2015/11/05-2015/11/09 (其他)	I-Ching Wang
2015	2015/10/15 2015/10/15	2015,2015/10/15 (其他)	I-Ching Wang
2015	2015/08/10 2015/08/11	2015,2015/08/10-2015/08/11 (其他)	I-Ching Wang
2014	2014/02/24 2014/02/27	2015,2014/02/24-2014/02/27	I-Ching Wang
2013	2013/11/04 2013/11/06	2013,2013/11/04-2013/11/06	I-Ching Wang
2013	2013/01/26 2013/01/25	2013,2013/01/26-2013/01/25	I-Ching Wang
2012	2012/11/26 2012/11/26	2015,2012/11/26	I-Ching Wang
2011	2011/08/14 2011/08/19	Wang IC, Snyder J, Zhang Y, Lander J, Nakafuku Y, Lin J, Chen G, Kalin TV, Whitsett JA and Kalinichenko VV.,Foxm1 Mediates a Cross-talk between Kras/MAPK and Canonical Wnt Signaling Pathways during Development of Respiratory Epithelium. ,Gordon Research Conference: Lung Development, Injury & Repair- Building and Rebuilding the Lung,Newport, Rhode Island,2011/08/14-2011/08/19 (其他)	I-Ching Wang
2011	2011/06/03 2011/06/03	Wang IC, Whitsett JA and Kalinichenko VV.,2011,The role of Foxm1 in Kras-induced lung tumorigenesis.,The National Lung Cancer Partnership 2011 Annual Meeting: Lung Cancer: Navigating the New Frontier,Chicago, IL,2011/06/03 (其他)	I-Ching Wang
2010	2010/08/08 2010/08/13	2010,Increased Expression of Foxm1 Transcription Factor in Respiratory Epithelium Inhibits Lung Sacculation and Caused Clara Cell Hyperplasia.,FASEB SUMMER RESEARCH CONFERENCES: The Lung Epithelium in Health and Disease,Saxtons River, Vermont.,2010/08/08-2010/08/13 (其他)	I-Ching Wang
2010	2010/01/11 2010/01/14	Wang IC, Kalin TV, Zhang Y, Snyder J, Whitsett JA and Kalinichenko VV. ,2012,The role of Foxm1 in lung cancer development: Transgenic gain of function and gene knock-out strategies.,AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Prospects for Personalized Prevention and Therapy,Coronado, CA,2010/01/11-2010/01/14 (其他)	I-Ching Wang
2009	2009/04/18 2009/04/22	Kalin TV, Wang IC, Meliton L, Ren X, Whitsett JA, Kalinichenko VV.,2009,Deletion of Forkhead box M1 transcription factor from lung epithelial cells inhibits pulmonary tumorigenesis. ,AACR 100th Annual meeting,Denver, CO,2009/04/18-2009/04/22 (其他)	I-Ching Wang
2008	2008/08/03 2008/08/08	Kalin TV, Wang IC, Meliton L, Zhang Y, Wert SE, Ren X, Snyder J, Whitsett, JA, Kalinichenoko, VV.,2008,Forkhead Box M1 Transcription Factor is Required for Perinatal lung Function. ,FASEB SUMMER RESEARCH CONFERENCES: Lung Epithelium in Development and Disease,Saxtons River, Vermont,2008/08/03-2008/08/08 (其他)	I-Ching Wang
2008	2008/04/12 2008/04/16	Wang IC, Meliton L, Costa RH, Kalinichenko VV, Kalin TV. ,2008,Transgenic expression of the Forkhead box M1 transcription factor induces formation of lung tumors.,AACR 99th Annual meeting,San Diego, CA,2008/04/12-2008/04/16 (其他)	I-Ching Wang
2006	2007/07/22 2006/07/27	Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Wang W, Yoder H, Ackerson T, Petrovic V, and Costa RH.,2006,A Cell Penetrating ARF Peptide Inhibitor of FoxM1 in Mouse Hepatocellular Carcinoma Treatment. ,FASEB SUMMER RESEARCH CONFERENCES: Liver Growth, Development and Disease,Snowmass Village, Colorado,2007/07/22-2006/07/27 (其他)	I-Ching Wang
2006	2006/07/22 2006/07/27	Wang IC, Hughes DE, Ackerson T, Major ML, and Costa RH.,2012,Diminished Progression into S-phase in Forkhead Box M1 Deficient Mammalian Cells is Associated with Reduced Expression of c-Jun NH2-Kinase 1 (JNK1) and ATF-2.,FASEB SUMMER RESEARCH CONFERENCES: Liver Growth, Development and Disease,Snowmass Village, Colorado,2006/07/22-2006/07/27 (其他)	I-Ching Wang
2006	2006/04/01 2006/04/05	Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Ackerson T, Petrovic V, and Costa RH. ,2006,A cell penetrating ARF peptide inhibitor of the Foxm1 transcription factor is an effective treatment for hepatocellular carcinoma In Vivo. ,AACR 97th Annual meeting,Washington, D.C.,2006/04/01-2006/04/05 (其他)	I-Ching Wang
2004	2004/10/06 2004/10/10	Wang IC and Costa RH. ,2004,Mouse embryonic fibroblasts without the forkhead Box M1B (FoxM1B) transcription factor fail to execute mitosis and exhibit premature senescence., Cold Spring Harbor Laboratory Molecular Genetics of Aging Meeting.,Cold Spring Harbor, New York.,2004/10/06-2004/10/10	I-Ching Wang
2004	2004/08/07 2004/08/12	Kalinichenko VV, Krupczak-Hollis K, Wang X, Gusarova GA, Wang IC, Dennewitz MB, Kiyokawa H, Kaestner KH and Costa RH. ,2004,The mouse Foxm1b transcription factor is essential for development of bile ducts and hepatic vessels during liver morphogenesis.,FASEB SUMMER RESEARCH CONFERENCES: Mechanisms of Liver Growth, Development and Disease.,Snowmass Village, Colorado,2004/08/07-2004/08/12 (其他)	I-Ching Wang

Participated event service summary
Category	Event title	Topic	Participant
(演講),(研討會)	The 1st International Conference on Life Science and Technology （ICoLiST）：Advanced technology development, Natural resource sustainability and human welfare.	Foxm1 transcription factor regulates lung adenocarcinoma development	I-Ching Wang
(演講),(研討會)	The National Lung Cancer Partnership 2011 Annual Meeting	Role of Foxm1 in Kras-induced lung tumorigenesis.	I-Ching Wang

Patent overview
Year	Patent category	Patent title	Date (Year/Month)	Patent owner
2019	其他	Computer-assisted diagnosis based on 3D image database	2018-00-00	I-Ching Wang / Chiang AS, Chang DT, Wang IC, Yang JL, Wu SC, Lin YY
2012	其他	“Method of inhibiting tumor cell proliferation”, a divisional application of US7635673, issued as U.S. Patent No. 7799896, September 21, 2010.	0000-00-00	I-Ching Wang / University of Illinois Board of Trustee
2011	其他	“Methods of Inhibiting Tumor Cell Proliferation with FoxM1 siRNA”. European Patent (EP) Pub. No. EP1758999 B1, Mar 09, 2011	0000-00-00	I-Ching Wang / University of Illinois Board of Trustee
2009	其他	“Methods of inhibiting tumor cell proliferation”. United States (US) Patent 7635673, December 22, 2009.	0000-00-00	I-Ching Wang / University of Illinois Board of Trustee

Research Projects
Year	Participant	Project period	Attached file/Reference link
107	I-Ching Wang	2018-01 ~ 2018-12	/
106	I-Ching Wang	2017-01 ~ 2017-12	/
105	I-Ching Wang	2016-08 ~ 2019-07	/
103	I-Ching Wang	2014-01 ~ 2017-12	/
102	I-Ching Wang	2013-01 ~ 2014-12	/
102	I-Ching Wang	2013-01 ~ 2013-10	/
102	I-Ching Wang	2013-08 ~ 2016-07	/

Industrial Collaboration
Year	Project name	Participant	Assignment	Project period	Subsidized / Entrusted organization	Attached file/Reference link	Notes
106		I-Ching Wang		2017-07 ~ 2018-12		/
105		I-Ching Wang		2016-01 ~ 2017-06		/

Honors & Awards (outside NTHU)
Year of award	Name of award	Awarded by
2012
2009	Career Development Award	National Lung Cancer Partnership, USA
2001	Fellowship	Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago

Educational background summary
School name	Country	Department	Degree	Starting date
University of Illinois at Chicago	USA	Molecular Genetics	Ph.D.	2001 ~ 2006
National Tsing Hua University	Taiwan	Life Science	M.S.	1995 ~ 1997
Tung Hai University	Taiwan	Biology	M.S.	1991-10 ~ 1995-06

Experiences
Service organization/unit	Title	Department	Starting date
Cincinnati Children's Hospital Medical Center	Research Associate	Neonatology and Pulmonary Biology	2007 ~ 2012
University of Chicago	Research Professional Associate	Pulmonary and Critical Care	2007 ~ 2007
University of Illinois at Chicago	Postdoctoral Research Associate	Biochemistry and Molecular Genetics	2006 ~ 2007
Academia Sinica	Research Assistant	Institute of Biomedical Sciences	1999 ~ 2001

Subject

必修
1. 專題討論　
2. 書報討論　
3. 分子與細胞生物學　
選修
1. 肺臟上皮發育與疾病特論　
2. 基因轉錄因子Forkheadbox蛋白特論　
3. 模式生物學　
4. 生醫研究小鼠模式

College of Life Science, National Tsing Hua University

Subject

標準版RSs 2.x套裝

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