Yu-Ting ChouPersonal data of - College of Life Science, National Tsing Hua University

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Name	Yu-Ting Chou

Category	Full-Time
Title	Associate Professor
單位別	Institute of Biotechnology / The Department of Life Sciences / Interdisciplinary Program of Life Science
Discipline	Molecular Diagnostics; New Drug Development; Molecular Biology; Medical Genetics
Research expertise	Cancer Biology; Cell Plasticity; Cytokine Signaling; Precision Medicine
Forum	Forum link

Recent Publications
Year	Publication	Author
2020	Kuo MH, Lee AC, Hsiao SH, Lin SE, Chiu YF, Yang LH, Yu CC, Chiou SH, Huang HN, Ko JC, Chou YT,2020,Crosstalk between SOX2 and TGF-beta signaling regulates EGFR-TKI tolerance and lung cancer dissemination,Cancer Research, (SCI)	Yu-Ting Chou
2020	Chiu YF, Wu CC, Kuo MH, Miao CC, Zheng MY, Chen PY, Lin SC, Chang JL, Wang YH, Chou YT ,2020,Critical role of SOX2–IGF2 signaling in aggressiveness of bladder cancer,Scientific Reports, (SCI)	Yu-Ting Chou
2020	Kuo YS, Zheng MY, Huang MF, Miao CC, Yang LH, Huang TW, Chou YT,2020,Association of Divergent Carcinoembryonic Antigen Patterns and Lung Cancer Progression,Scientific Reports,10,1,pp2066- (SCI)	Yu-Ting Chou
2020	Kuo PH, Teng YH, Cin AL, Han W, Huang PW, Wang LH, Chou YT, Yang JL, Tseng YL, Kao M, Chang MD,2020,Heparan sulfate targeting strategy for enhancing liposomal drug accumulation and facilitating deep distribution in tumors,Drug Delivery,27,1,pp542-555	Yu-Ting Chou
2019	Lin SC, Chung CH, Chung CH, Kuo MH, Hsieh CH, Chiu YF, Shieh YS, Chou YT and Wu CW. ,2019,OCT4B mediates hypoxia-induced cancer dissemination,Oncogene, 38,7,pp1093-1105 (SCI)	Yu-Ting Chou
2019	Hsu SY, Yu HY, Lee WC, Hsiao CE, Wu CL, Cheng HT, Lin LJ, Li F, Chou YT and Cheng JW,2019,A novel CXCL8 analog is effective in inhibiting the growth via cell cycle arrest and attenuating invasion of Lewis lung carcinoma,OncoTargets and Therapy,12,pp7611-7621 (SCI)	Yu-Ting Chou
2018	Lee CJ, Sung PL, Kuo MH, Tsai MH, Wang CK, Pan ST, Chen YJ, Wang PH, Wen KC, Chou YT,2018,Crosstalk between SOX2 and cytokine signaling in endometrial carcinoma,Scientific Reports, (SCI)	Yu-Ting Chou
2018	Wen KC, Sung PL, Chou YT, Pan CM, Wang PH, Lee OK, Wu CW,2018,The role of EpCAM in tumor progression and the clinical prognosis of endometrial carcinoma,Gynecologic Oncology,148,2,pp383-392 (SCI)	Yu-Ting Chou
2018	Tsai CC, Chou YT, Fu HW,2018,Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells,Biochimica Et Biophysica Acta-Molecular Cell Research,1866,3,pp486 -503 (SCI)	Yu-Ting Chou
2017	Hwang W, Chiu YF, Kuo MH, Lee KL, Lee AC, Yu CC, Chang JL, Huang WC, Hsiao SH, Lin SE, Chou YT* ,2017,Expression of neuroendocrine factor VGF in lung cancer cells confers resistance to EGFR kinase inhibitors and triggers epithelial-to-mesenchymal transition,Cancer Research,77,11,pp3013-3026 (SCI)	Yu-Ting Chou
2017	Hsieh CH, Chou YT, Kuo MH, Tsai HP, Chang JL, Wu CW,2017,A Targetable HB-EGF–CITED4 Axis Controls Oncogenesis in Lung Cancer,Oncogene,36,21,pp2946-2956 (SCI)	Yu-Ting Chou
2017	Hsiao SH, Chou YT, Lin SE, Hsu RC, Chung CL, Kao YR, Liu HE, Wu CW,2017,Brain metastases in patients with non-small cell lung cancer: the role of mutated-EGFRs with an exon 19 deletion or L858R point mutation in cancer cell dissemination,Oncotarget,[Epub ahead of print], (SCI)	Yu-Ting Chou
2017	Wen KC, Sung PL, Hsieh SL, Chou YT, Lee OK, Wu CW, Wang PH,2017,α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells,Oncotarget, 8,17,pp29013-29027 (SCI)	Yu-Ting Chou
2017	Wang SS, Chou YT, Pu YS,2017,Antagonistic effect of N-ethylmaleimide on arsenic-mediated oxidative stress-induced poly(ADP-ribosyl)ation and cytotoxicity,Journal of Applied Toxicology,37,5,pp573-582 (SCI)	Yu-Ting Chou
2017	Chan SM, Lin BF, Wong CS, Chuang WT, Chou YT, Wu ZF,2017,Levobuipivacaine-Induced Dissemination of A549 Lung Cancer Cells,Scientific Reports,7,1,pp8646- (SCI)	Yu-Ting Chou
2017	Lam IF, Huang M, Chang MD, Yao PW, Chou YT, Ng SK, Tsai YL, Lin YC, Zhang YF, Yang XY, Lai YK,2017,Identification of anti-HBV activities in Paeonia suffruticosa Andr. using GRP78 as a drug target on Herbochip®,Chinese Medicine,12 ,11, (SCI)	Yu-Ting Chou
2016	Lin SC, Chou YT, Jiang SS, Chang JL, Chung CH, Kao YR, Chang IS, Wu CW,2016,Epigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity.,Cancer Research,76,23,pp7036-7048 (SCI)	Yu-Ting Chou
2016	Wang SS, Chen CH, Chou YT, Pu YS,2016,Perioperative changes in TGF-β1 levels predict the oncological outcome of cryoablation-receiving patients with localized prostate cancer.,Cryobiology,73,1,pp63-8 (SCI)	Yu-Ting Chou
2016	Cheng JC, Chiang MT, Lee CH, Liu SY, Chiu KC, Chou YT, Huang RY, Huang SM, Shieh YS. ,2016,γ-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma. , J Dent Res.,95,4,pp439-45 (SCI)	Yu-Ting Chou
2015	Chih YH, Lin YS, Yip BS, Wei HJ, Chu HL, Yu HY, Cheng HT, Chou YT, Cheng JW.,2015,Ultrashort Antimicrobial Peptides with Antiendotoxin Properties.,Antimicrob Agents Chemother.,8,59,pp5052-5056 (SCI)	Yu-Ting Chou
2015	Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, Khoo KH, Chang GD, Wu CW, Meng TC, Chen GC.,2015,Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation.,Oncogene.,29,34,pp3791-3803 (SCI)	Yu-Ting Chou
2015	Ciou SC, Chou YT, Liu YL, Nieh YC, Lu JW, Huang SF, Chou YT, Cheng LH, Lo JF, Chen MJ, Yang MC, Yuh CH, Wang HD.,2015,Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling.,Int J Cancer.,137,1,pp104-115 (SCI)	Yu-Ting Chou
2015	Chiu KC, Lee CH, Liu SY, Chou YT, Huang RY, Huang SM, Shieh YS.,2015,Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinoma.,Oral Oncol.,7,51,pp683-689	Yu-Ting Chou
2015	Chu HL, Yip BS, Chen KH, Yu HY, Chih YH, Cheng HT, Chou YT, Cheng JW.,2015,Novel antimicrobial peptides with high anticancer activity and selectivity.,PLoS One.,5,10,ppe0126390- (SCI)	Yu-Ting Chou
2014	Chiu KC, Lee CH, Liu SY, Yeh CT, Huang RY, Yuh DY, Cheng JC, Chou YT, Shieh YS.,2014,Protumoral effect of macrophage through Axl activation on mucoepidermoid carcinoma.,J Oral Pathol Med. ,7,43,pp538-544	Yu-Ting Chou
2014	Hsiao SH, Lin SE, Chou YT, Wang JL, Chung CL, Yu MC, Fang CL, Lee HL, Chiang LL, Liu HE, Wu CW.,2014,Histological subtype and smoking status, but not gender, are associated with epidermal growth factor receptor mutations in non-small-cell lung cancer. cancer.,Mol Clin Oncol.,2,2,pp252-258 (SCI)	Yu-Ting Chou
2013	Hsiao SH, Chung CL, Lee CM, Chen WY, Chou YT, Wu ZH, Chen YC, Lin SE.,2013,Suitability of Computed Tomography-Guided Biopsy Specimens for Subtyping and Genotyping of Non-Small-Cell Lung Cancer.,Clin Lung Cancer,6,14,pp719-725 (SCI)	Yu-Ting Chou
2013	Hsiao SH, Chung CL, Chou YT, Lee HL, Lin SE, Liu HE.,2013,Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases.,Lung Cancer,2,82, (SCI)	Yu-Ting Chou
2013	Chou YT, Lee CC, Hsiao SH, Lin SE, Lin SC, Chung CH, Chung CH, Kao YR, Wang YH, Chen CT, Wei YH, Wu CW,2013,The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer,Stem Cells,12,37,pp2607-2619 (SCI)	Yu-Ting Chou
2013	3. Hsiao SH, Lin HC, Chou YT, Lin SE, Kuo CC, Yu MC, Chung CL.,2013,Impact of epidermal growth factor receptor mutations on intracranial treatment response and survival after brain metastases in lung adenocarcinoma patients.,Lung Cancer,3,81,pp455-461 (SCI)	Yu-Ting Chou
2013	Kuo HY, Chen YC, Chang HY, Jeng JC, Lin EH, Pan CM, Chang YW, Wang ML, Chou YT, Shih HM, Wu CW.,2013,The PML isoform IV is a negative regulator of nuclear EGFR's transcriptional activity in lung cancer.,Carcinogenesis,8,34,pp1708-1716 (SCI)	Yu-Ting Chou
2012	Chou YT, Hsieh CH, Chiou SH, Hsu CF, Kao YR, Lee CC, Chung CH, Wang YH, Hsu HS, Pang ST, Shieh YS, Wu CW. ,2012,CITED2 functions as a molecular switch of cytokine-induced proliferation and quiescence.,Cell Death Differ,19,12,pp2015-28 (SCI)	Yu-Ting Chou
2010	Lau WM, Weber KL, Doucet M, Chou YT, Brady K, Kowalski J, Tsai HL, Yang J, Kominsky SL.,2010,Identification of prospective factors promoting osteotropism in breast cancer: a potential role for CITED2.,Int J Cancer. ,126,4,pp876-884 (SCI)	Yu-Ting Chou
2010	Chou YT, Lin HH, Lien YC, Wang YH, Hong CF, Kao YR, Lin SC, Chang YC, Lin SY, Chen SJ, Chen HC, Yeh SD, and Wu CW.,2010,EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF.,Cancer Res. ,70,21,pp8822-8831 (SCI)	Yu-Ting Chou
2010	Chiou SH, Wang ML, Chou YT, Chen CJ, Hong CF, Hsieh WJ, Chang HT, Chen YS, Lin TW, Hsu HS, Wu CW.,2010,Coexpression of Oct4 and Nanog enhance malignancy in lung adenocarcinoma by inducing cancer stem cell-Like properties and epithelial-mesenchymal transdifferentiation.,Cancer Res.*,70,24,pp10433-442010 (SCI)	Yu-Ting Chou
2009	Hong CF, Chou YT, Lin YS, Wu CW.,2009,MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.,J Biol Chem. ,284 ,29,pp19613-19622 (SCI)	Yu-Ting Chou
2007	Qu X, Doughman YQ, Chen Y, Chou YT, Lam E, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC.,2007,Cited2, a coactivator of HNF4alpha, is essential for liver development.,EMBO J. ,26,21,pp4445-4456 (SCI)	Yu-Ting Chou
2006	Chou YT and Yang YC.,2006,Posttranscriptional Control of Cited2 by TGF-beta: regulation via Smads and Cited2 coding region.,J Biol Chem. ,281,27,pp18451-18462 (SCI)	Yu-Ting Chou
2006	Chou YT, Wang H, Danielpour D, Chen Y and Yang YC.,2006,Cited2 modulates TGF-beta-mediated upregulation of MMP9.,Oncogene ,25,40,pp5547-5560 (SCI)	Yu-Ting Chou

Seminar paper summary
Year	Conference period	Publication	Author
2019	2019/03/29 2019/04/03	Miao CC, Hwang W, Chou YT,2019,Heterogeneous LC3A expression regulates lung cancer cell plasticity,American Association for Cancer Research （AACR） Annual Meeting ,Atlanta, Georgia, U.S.A.,2019/03/29-2019/04/03	Yu-Ting Chou
2018	2018/04/14 2018/04/18	Lee AC, Yu CC, Wang YH, Chou YT.,2018,EGFR and SOX2 crosstalk determines EGFR-TKI sensitivity and tumor progression .,American Association for Cancer Research （AACR） Annual Meeting ,Chicago, Illinois, U.S.A.,2018/04/14-2018/04/18	Yu-Ting Chou
2017	2017/04/01 2017/04/05	Lee AC, Chiu YF, Kuo MH, Chou YT,2017,Crosstalk of SOX2 and epithelial-to-mesenchymal transition on lung cancer progression,American Association for Cancer Research （AACR） Annual Meeting ,Washington D.C., U.S.A.,2017/04/01-2017/04/05	Yu-Ting Chou
2016	2016/04/16 2016/04/20	Chiu YF, Kuo MH, Lee AC, Chou YT,2016,The emerging role of SOX2 in cancer cell plasticity and EGFR-TKI resistance,American Association for Cancer Research （AACR） Annual Meeting ,New Orleans, Louisiana, U.S.A.,2016/04/16-2016/04/20	Yu-Ting Chou
2015	2015/04/18 2015/04/22	Hsieh CH, Chou YT, and Wu CW. ,2015,HB-EGF−mediated CITED4 signaling in lung cancer.,American Association for Cancer Research （AACR） Annual Meeting 2015, Philadelphia, Pennsylvania, U.S.A.,2015/04/18-2015/04/22	Yu-Ting Chou
2015	2015/04/18 2015/04/22	Kuo MH, Hsieh CH, Wang YH, Wu CW, and Chou YT.,2015,Emerging role of CITED2 in hypoxia and TGFbeta mediated proliferation and invasion in lung cancer., （AACR） Annual Meeting 2015,Philadelphia, Pennsylvania, U.S.A.,2015/04/18-2015/04/22	Yu-Ting Chou
2014	2014/04/05 2014/04/09	Wang YH, Huang CF, Kuo MH, Wu CW, and Chou YT.,2014,CITED2 as a molecular switch for hypoxia-mediated proliferation. American Association for Cancer ,Research （AACR） Annual Meeting 2014, San Diego, California, U.S.A.,2014/04/05-2014/04/09	Yu-Ting Chou
2013	2013/04/06 2013/04/10	Yu-Ting Chou, Chih-Chan Lee, Shih-Hsin Hsiao, Sey-En Lin, Sheng-Chieh Lin, Yuan-Hung Wang, and Cheng-Wen Wu,2013,SOX2-mediated cell survival and chemoresistance in lung cancer,American Association for Cancer Research （AACR） 104nd Annual Meeting 2013,Washington D.C., USA,2013/04/06-2013/04/10 (其他)	Yu-Ting Chou
2012	2012/03/31 2012/04/04	Chou YT, Chung CH, Chung C, Wu CW.,2012,Oct4B Mediates Hypoxia Induced Epithelial Mesenchymal Trans-differentiation of Lung Cancer.,American Association for Cancer Research （AACR） Annual Meeting,Chicago, IL, USA,2012/03/31-2012/04/04 (其他)	Yu-Ting Chou
2011	2011/04/02 2011/04/06	Chou YT, Lee CC, Lin SC, Wu CW.,2011,A Sox2-EGFR Positive Feedback Loop Contributes to Oncogenesis of Lung Cancer., American Association for Cancer Research （AACR） Annual Meeting,Orlando, FL, USA,2011/04/02-2011/04/06 (其他)	Yu-Ting Chou
2010	2010/04/17 2010/04/21	Chou YT, Hsu CF, Kao YR, and Wu CW.,2010,Cited2, a novel EGFR-induced coactivator, plays a key role in lung cancer progression.,American Association for Cancer Research （AACR） Annual Meeting,Washington, DC, USA,2010/04/17-2010/04/21 (其他)	Yu-Ting Chou
2009	2009/07/08 2009/07/11	Chou YT, Chen CJ, Chiou SH, Hsieh WJ, Wang ML, Wu CW.,2009,Role of embryonic stem cell signaling in cancer progression.,International Society for Stem Cell Research （ISSCR） 7th Annual Meeting,Barcelona, Spain,2009/07/08-2009/07/11 (其他)	Yu-Ting Chou
2009	2009/04/18 2009/04/22	Lin HH, Chou YT, Wu CW.,2009,mir-7, an EGFR induced microRNA, modulates lung cancer progression,American Association for Cancer Research （AACR） 100th Annual Meeting,Denver, Co, USA ,2009/04/18-2009/04/22 (其他)	Yu-Ting Chou
2003	2003/12/06 2003/12/09	Chou YT and Yang YC.,2003,Cited2 is a transcriptional modulator in TGF-beta signaling pathway. ,American Society of Hematology （ASH） Meeting,San Diego, CA, USA,2003/12/06-2003/12/09 (其他)	Yu-Ting Chou

Educational background summary
School name	Country	Department	Degree	Starting date
Case Western Reserve University	USA	Pharmacology	Ph.D.	2000 ~ 2006
National Yang-Ming University	Taiwan	Microbiology and Immunology	M.S.	1994 ~ 1996
Chinese Culture University	Taiwan	Biology	B.S.	1990 ~ 1994

Experiences
Service organization/unit	Title	Department	Starting date
National Tsing Hua University	Assistant Professor	Institute of Biotechnology	2012-08 ~
Academia Sinica	Postdoctoral Scholar	Institute of Biomedical Sciences	2008 ~ 2012
National Health Research Institutes	Postdoctoral fellow	National Institute of Cancer Research	2007 ~ 2008
Johns Hopkins Medical Institutions	Postdoctoral fellow	Department of Orthopaedic Surgery and Oncology	2006 ~ 2006

Subject

選修
1. Special topics on translational cancer research

College of Life Science, National Tsing Hua University

Subject

標準版RSs 2.x套裝

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