呂平江的個人資料 - 清華大學生命科學院

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姓名	呂平江
傳真	03-5715934
個人網站	http://biobug.life.nthu.edu.tw/
個人研究計畫參考網址	請點選這裡

類別	專任師資
職稱	教授
單位別	生物資訊與結構生物研究所 / 學士班 / 醫科系
授課領域	結構生物、生物資訊、蛋白質工程
研究專長	蛋白質結構及生物資訊學(以下是最近幾年的研究主題) * 脂質傳送蛋白(Lipid Transfer Proteins (LTPs))的結構、折疊和功能性研究 * 葡聚醣之結合胜呔設計 * 胃幽門桿菌(Helicobacter Pylori)結構基因體計畫 * 生物資訊在結構生物上的應用

期刊論文一覽
年度	著作	著作人
2011	Cheng, C.S., Chen, W.T., Lee, L.H., Chen, Y.W., Chang, S.Y., Lyu, P.C. and Yin, H.S.,2011,Structural and functional comparison of cytokine interleukin-1 beta from chicken and human,Molecular Immunology,48,6-7,pp947-955 (SCI)	呂平江
2011	Chang, C.W., Lyu, P.C. and Arita, M.,2011,Reconstructing phylogeny from metabolic substrate-product relationships,BMC Bioinformatics,12,S1, (SCI)	呂平江
2011	Yang, J.T., Chen, C.K., Hu, I.C. and Lyu, P.C,2007,Design of a self-flapping microfluidic oscillator and diagnosis with fluorescence methods,Journal of Microelectromechanical Systems,16,4,pp826-835 (SCI)	呂平江
2010	Peng, Y.H., Coumar, M.S., Leou, J.S., Wu, J.S., Shiao, H.Y., Lin, C.H., Lin, W.H., Lien, T.W., Chen, X., Hsu, J.T.A., Chao, Y.S., Huang, C.F., Lyu, P.C., Hsieh, H.P. and Wu, S.Y. ,2010,Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists,Chemmedchem,5,10,pp1707-1716 (SCI)	呂平江
2010	Wey, M.T., Lyu, P.C. and Kan, L.S. ,2010,Thermodynamic and Kinetic Studies of a Stable Imperfect DNA Triplex by Spectroscopic and Calorimetric Methods,Journal of the Chinese Chemical Society,57,3B,pp496-504 (SCI)	呂平江
2010	Tseng, H.C., Lyu, P.C. and Lin, W.C.,2010,Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain,BMC Cell Biology,11,pp48- (SCI)	呂平江
2010	Pan, T.L., Hung, Y.C., Wang, P.W., Chen, S.T., Hsu, T.K., Sintupisut, N., Cheng, C.S. and Lyu, P.C.,2010,Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells,Proteomics,10,5,pp914-929 (SCI)	呂平江
2010	Lee, T.S., Pan, C.C., Peng, C.C., Kou, Y.R., Chen, C.Y., Ching, L.C., Tsai, T.H., Chen, S.F., Lyu, P.C. and Shyue, S.K,2010,Anti-Atherogenic Effect of Berberine on LXR alpha-ABCA1-Dependent Cholesterol Efflux in Macrophages,Journal of Cellular Biochemistry,111,1,pp104-110 (SCI)	呂平江
2010	Huang, P.J., Liu, Y.C., Lee, C.C., Lin, W.C., Gan, R.R.C., Lyu, P.C.* and Tang, P. ,2010,DSAP: deep-sequencing small RNA analysis pipeline,Nucleic Acids Research,38,S2,ppW385-W391 (SCI)	呂平江
2010	Huang, H. L., Hsing, H.W., Lai, T.C., Chen, Y.W., Lee, T.R., Chan, H.T., Lyu, P.C., Wu, C.L., Lu, Y.C., Lin, S.T., Lin, C.W., Lai, C.H., Chang, H.T., Chou, H.C. and Chan, H.L.,2010,Trypsin-induced proteome alteration during cell subculture in mammalian cells,Journal of Biomedical Science,17,pp36- (SCI)	呂平江
2010	Hsu, R.M., Tsai, M.H., Hsieh, Y.J., Lyu, P.C. and Yu, J.S,2010,Identification of MYO18A as a Novel Interacting Partner of the PAK2/beta PIX/GIT1 Complex and Its Potential Function in Modulating Epithelial Cell Migration,Molecular Biology of the Cell,21,2,pp287-301 (SCI)	呂平江
2010	Hsieh, Y.J., Yu, J.S. and Lyu, P.C.,2010,Characterization of Photodynamic Therapy Responses Elicited in A431 Cells Containing Intracellular Organelle-Localized Photofrin,Journal of Cellular Biochemistry ,111,4,pp821-833 (SCI)	呂平江
2010	Ho, M.R., Lou, Y.C., Wei, S.Y., Luo, S.C., Lin, W.C., Lyu, P.C. and Chen, C.P,2010,Human RegIV Protein Adopts a Typical C-Type Lectin Fold but Binds Mannan with Two Calcium-Independent Sites,Journal of Molecular Biology ,402,4,pp682-695 (SCI)	呂平江
2010	Chu, C.H., Lo, W.C., Wang, H.W., Hsu, Y.C., Hwang, J.K., Lyu, P.C., Pai, T.W. and Tang, C.Y,2010,Detection and Alignment of 3D Domain Swapping Proteins Using Angle-Distance Image-Based Secondary Structural Matching Techniques,PLOS One,5,10, (SCI)	呂平江
2010	Chou, H.C., Chen, Y.W., Lee, T.R., Wu, F.S., Chan, H.T., Lyu, P.C., Timms, J.F. and Chan, H.L.,2010,Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment,Free Radical Biology and Medicine,49,1,pp96-108 (SCI)	呂平江
2010	Chen, J.C., Uang, B.J., Lyu, P.C., Chang, J.Y., Liu, K.J., Kuo, C.C., Hsieh, H.P., Wang, H.C., Cheng, C.S., Chang, Y.H., Chang, M.D.T., Chang, W.S.W. and Lin, C.C. ,2010,Design and Synthesis of alpha-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis,Journal of Medicinal Chemistry,53,11,pp4545-4549 (SCI)	呂平江
2009	Yang, Y.F., Cheng, K.C., Tsai, P.H., Liu, C.C., Lee, T.R. and Lyu, P.C.,2009,Alanine substitutions of noncysteine residues in the cysteine-stabilized alpha beta motif,Protein Science ,18,7,pp1498-1506 (SCI)	呂平江
2009	Lo, W.C., Lee, C.Y., Lee, C.C. and Lyu, P.C.,2009,iSARST: an integrated SARST web server for rapid protein structural similarity searches,Nucleic Acids Research ,37,ppW545-W551 (SCI)	呂平江
2009	Lo, W.C., Lee, C.C., Lee, C.Y. and Lyu, P.C.,2009,CPDB: a database of circular permutation in proteins,Nucleic Acids Research,37,ppD328-D332 (SCI)	呂平江
2009	Lo, A., Chiu, Y.Y., Rodland, E.A., Lyu, P.C., Sung, T.Y. and Hsu, W.L.,2009,Predicting helix-helix interactions from residue contacts in membrane proteins,Bioinformatics,25,8,pp996-1003 (SCI)	呂平江
2009	Ku, T.H., Lu, P.Y., Chan, C.H., Wang, T.S., Lai, S.Z., Lyu, P.C. and Hsiao, N.W,2009,Predicting melting temperature directly from protein sequences,Computational Biology and Chemistry ,33,6,pp445-450 (SCI)	呂平江
2009	Chiang, Y.K., Kuo, C.C., Wu, Y.S., Chen, C.T., Coumar, M.S., Wu, J.S., Hsieh, H.P., Chang, C.Y., Jseng, H.Y., Wu, M.H., Leou, J.S., Song, J.S., Chang, J.Y., Lyu, P.C., Chao, Y.S. and Wu, S.Y,2009,Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity,Journal of Medicinal Chemistry ,52,14,pp4221-4233 (SCI)	呂平江
2009	Chen, T., Lee, T.R., Liang, W.G., Chang, W.S.W. and Lyu, P.C.,2009,Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor,Proteins-Structure Function and Bioinformatics,77,1,pp209-219 (SCI)	呂平江
2008	Yang, Y.F., Chou, M.Y., Fan, C.Y., Chen, S.F., Lyu, P.C., Liu, C.C. and Tseng, T.L,2008,The possible interaction of CDA14 and protein elongation factor 1 alpha,Biochimica Et Biophysica Acta-Proteins and Proteomics,1784,2,pp312-318 (SCI)	呂平江
2008	Lo, W.C. and Lyu, P.C.,2008,CPSARST: an efficient circular permutation search tool applied to the detection of novel protein structural relationships,Genome Biology,9,1,ppR11- (SCI)	呂平江
2008	Lo, A., Chiu, H.S., Sung, T.Y., Lyu, P.C. and Hsu, W.L,2008,Enhanced membrane protein topology prediction using a hierarchical classification method and a new scoring function, Journal of Proteome Research,7,2,pp487-496 (SCI)	呂平江
2008	Liao, C.J., Chin, K.H., Lin, C.H., Tsai, P.S.F., Lyu, P.C., Young, C.C., Wang, A.H.J. and Chou, S.H.,2008,Crystal structure of DFA0005 complexed with alpha-ketoglutarate: A novel member of the ICL/PEPM superfamily from alkali-tolerant Deinococcus ficus,Proteins-Structure Function and Bioinformatics ,73,2,pp362-371 (SCI)	呂平江
2008	Lai, Y.T., Cheng, C.S., Liu, Y.N., Liu, Y.J. and Lyu, P.C.,2008,Effects of ligand binding on the dynamics of rice nonspecific lipid transfer protein 1: A model from molecular simulations,Proteins-Structure Function and Bioinformatics,72,4,pp1189-1198 (SCI)	呂平江
2008	Hsiao, C.J., Li, T.K., Chan, Y.L., Hsin, L.W., Liao, C.H., Lee, C.H., Lyu, P.C. and Guh, J.H.,2008,WRC-213, an L-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers,Biochemical Pharmacology,75,4,pp847-856 (SCI)	呂平江
2008	Hsiao, C.J., Ho, Y.F., Hsu, J., Chang, W.L., Chen, Y.C., Shen, Y.C., Lyu, P.C. and Guh, J.H.,2008,Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress,Naunyn-Schmiedebergs Archives of Pharmacology,378,6,pp599-608 (SCI)	呂平江
2008	Cheng, C.S., Chen, M.N., Lai, Y.T., Chen, T., Lin, K.F., Liu, Y.J. and Lyu, P.C,2008,Mutagenesis study of rice nonspecific lipid transfer protein 2 reveals residues that contribute to structure and ligand binding,Proteins-Structure Function and Bioinformatics,70,3,pp695-706 (SCI)	呂平江
2007	Lin, S.C., Chueh, S.C., Hsiao, C.J., Li, T.K., Chen, T.H., Liao, C.H., Lyu, P.C., and Guh, J.H,2007,Prazosin displays anticancer activity against human prostate cancers: Targeting DNA and cell cycle,Neoplasia,9,10,pp830-839 (SCI)	呂平江
2007	Lo, W.C., Huang, P.J., Chang, C.H. and Lyu, P.C,2007,Protein structural similarity search by Ramachandran codes,BMC Bioinformatics,8,pp307- (SCI)	呂平江
2007	Yang, J.T., Huang, K.J., Tung, K.Y., Hu, I.C. and Lyu, P.C,2007,A chaotic micromixer modulated by constructive vortex agitation, Journal of Micromechanics and Microengineering,17,10,pp2084-2092 (SCI)	呂平江
2007	Lin, K.F., Lee, T.R., Tsai, P.H., Hsu, M.P., Chen, C.S. and Lyu, P.C,2007,Structure-based protein engineering for alpha-amylase inhibitory activity of plant defensin, Proteins-Structure Function and Bioinformatics,68,2,pp530-540 (SCI)	呂平江
2007	Liu, Y.N., Lai, Y.T., Chou, W.I., Chang, M.D.T. and Lyu, P.C,2007,Solution structure of family 21 carbohydrate-binding module from Rhizopus oryzae glucoamylase,Biochemical Journal,403,pp21-30 (SCI)	呂平江
2007	Wang, L.L., Yang, J.T. and Lyu, P.C,2007,An overlapping crisscross micromixer,Chemical Engineering Science,62,3,pp711-720 (SCI)	呂平江
2007	Ruan, S.K., Chin, K.H., Shr, H.L., Lyu, P.C., Wang, A.H.J. and Chou, S.H,2007,Preliminary X-ray analysis of XC5848, a hypothetical ORFan protein with an Sm-like motif from Xanthomonas campestris,Acta Crystallographica Section F-Structural Biology and Crystallization Communications,63,pp30-33 (SCI)	呂平江
2007	Yang, J.T., Chen, C.K., Hu, I.C. and Lyu, P.C,2007,Design of a self-flapping microfluidic oscillator and diagnosis with fluorescence methods,Journal of Microelectromechanical Systems,16,4,pp826-835 (SCI)	呂平江
2006	Lin, C.W., Lin, K.H., Lyu, P.C., and Chen, W.J,2006,apanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper,Virus Research,116,1-2,pp106-113 (SCI)	呂平江
2006	Mahindroo, N., Wang, C.C., Liao, C.C., Huang, C.F., Lu, I.L., Lien, T.W., Peng, Y.H., Huang, W.J., Lin, Y.T., Hsu, M.C., Lyu, P.C., Chao, Y.S., Wu, S.Y., and Hsieh, H.P,2006,Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists：Design, synthesis, structural biology, and molecular docking studies,Journal of Medicinal Chemistry,49,3,pp1212-1216 (SCI)	呂平江
2006	Ho, M.R., Lou, Y.C., Lin, W.C., Lyu, P.C., Huang, W.N. and Chen, C,2006,Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation,Journal of Biological Chemistry ,281,44,pp33566-33576 (SCI)	呂平江
2006	Mahindroo, N., Peng, Y.H., Lin, C.H., Tan, U.K., Prakash, E., Lien, T.W., Lu, I.L., Lee, H.J., Hsu, J.T.A., Chen, X., Liao, C.C., Lyu, P.C., Chao, Y.S., Wu, S.Y. and Hsieh, H.P,2006,Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists,Journal of Medicinal Chemistry,49,21,pp6421-6424 (SCI)	呂平江
2006	Hu, I.C., Lee, T.R., Lin, H.F., Chiueh, C.C., and Lyu, P.C,2006,Biosynthesis of fluorescent allophycocyanin alpha-subunits by autocatalytic bilin attachment,Biochemistry ,45,23,pp7092-7099 (SCI)	呂平江
2006	Liu, Y.J., Cheng, C.S., Lai, S.M., Hsu, M.P., Chen, C.S., and Lyu, P.C,2006,Solution structure of the plant defensin VrD1 from mung bean and its possible role in insecticidal activity against bruchids,Proteins-Structure Function and Bioinformatics,63,4,pp777-786 (SCI)	呂平江
2006	Tsai, J.Y., Chen, B.T., Cheng, H.C., Chen, H.C., Hsaio, N.W., Lyu, P.C., and Sun, Y.J,2006,Crystal structure of HP02429, a hypothetical protein from Helicobaccter pylori wrath a novel fold,Proteins-Structure Function and Bioinformatics,62,4,pp1138-1143 (SCI)	呂平江
2006	Lo, W.T., Chin, K.H., Shr, H.L., Gao, F.P., Lyu, P.C., Wang, A.H.J. and Chou, S.H,2006,Crystallization and preliminary X-ray analysis of XC1015, a histidine triad-like protein from Xanthomonas campestris,Acta Crystallographica Section F-Structural Biology and Crystallization Communications,62,pp1263-1265 (SCI)	呂平江
2006	Lin, C.H., Chin, K.H., Gao, F.P., Lyu, P.C., Shr, H.L., Wang, A.H.J. and Chou, S.H,2006,Cloning, crystallization and preliminary X-ray studies of XC2981 from Xanthomonas campestris, a putative CutA1 protein involved in copper-ion homeostasis,Acta Crystallographica Section F-Structural Biology and Crystallization Communications,62,pp1113-1115 (SCI)	呂平江
2006	Tsai, Y.D., Chin, K.H., Shr, H.L., Gao, F.P., Lyu, P.C., Wang, A.H.J. and Chou, S.H.,2006,Cloning, crystallization and preliminary X-ray study of XC1258, a CN-hydrolase superfamily protein from Xanthomonas campestris,Acta Crystallographica Section F-Structural Biology and Crystallization Communications ,62,pp999-1002 (SCI)	呂平江
2006	Chio, K.C., Chin, K.H., Gao, F.P., Lyu, P.C., Shr, H.L., Wang, A.H.J. and Chou, S.H,2006,The cloning, crystallization and preliminary X-ray analysis of XC2113, a YaeQ protein from Xanthomonas campestris,Acta Crystallographica Section F-Structural Biology and Crystallization Communications,62,pp1046-1048 (SCI)	呂平江

其他著作

期刊論文
1. C. J. Liao, K. H. Chin, C. H. Lin, P.S. Tsai, P. C. Lyu, Y. C. Coung, A. H. Wang, S. H. Chou. Proteins: Structure, Function, Bioinformatics. 73, 362-371(2008).
2. Proteins: Structure, Function, Bioinformatics. Y. T. Lai*. 72 , 1189-1198 (2008)., C. S. Cheng, K. F. Lin, Y. J. Liu, P. C. Lyu
3. A. Lo, H. S. Chiu, T. Y. Sung, P. C. Lyu, W. L. Hsu. J Proteome Res . 7, 487-496 (2008).

學歷一覽
學校名稱	國別	系所	學位	起迄年月
美國紐約大學	美國	化學系	博士	1987年09月 ~ 1991年05月
紐澤西理工學院	美國	化學	碩士	1985年09月 ~ 1987年05月
東海大學	台灣	化學	學士	1978年09月 ~ 1982年06月

服務機關	職稱	部門/系所	起迄年月
國立清華大學	教授	醫學科學系	2011年08月 ~ 2012年07月
國立清華大學	教授	生命科學系	2002年02月 ~ 2011年08月
國立清華大學	副教授	生命科學系	1994年08月 ~ 2002年02月
美國加州大學柏克萊分校	博士後研究員	化學系	1991年12月 ~ 1994年06月

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