Ping-Chiang LyuPersonal data of - College of Life Science, National Tsing Hua University

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Name	Ping-Chiang Lyu
Fax	03-5715934
Personal website	http://biobug.life.nthu.edu.tw/
Reference website of individual research	Please click here

Category	Full-Time
Title	Professor
單位別	Institute of Bioinformatics and Structural Biology / Interdisciplinary Program of Life Science / Department of Medical Science
Discipline	Biophysics/Structural Biology
Research expertise	Biophysics/Structural Biology

Recent Publications
Year	Publication	Author
2011	Cheng, C.S., Chen, W.T., Lee, L.H., Chen, Y.W., Chang, S.Y., Lyu, P.C. and Yin, H.S.,2011,Structural and functional comparison of cytokine interleukin-1 beta from chicken and human,Molecular Immunology,48,6-7,pp947-955 (SCI)	Ping-Chiang Lyu
2011	Chang, C.W., Lyu, P.C. and Arita, M.,2011,Reconstructing phylogeny from metabolic substrate-product relationships,BMC Bioinformatics,12,S1, (SCI)	Ping-Chiang Lyu
2011	Yang, J.T., Chen, C.K., Hu, I.C. and Lyu, P.C,2007,Design of a self-flapping microfluidic oscillator and diagnosis with fluorescence methods,Journal of Microelectromechanical Systems,16,4,pp826-835 (SCI)	Ping-Chiang Lyu
2010	Peng, Y.H., Coumar, M.S., Leou, J.S., Wu, J.S., Shiao, H.Y., Lin, C.H., Lin, W.H., Lien, T.W., Chen, X., Hsu, J.T.A., Chao, Y.S., Huang, C.F., Lyu, P.C., Hsieh, H.P. and Wu, S.Y. ,2010,Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists,Chemmedchem,5,10,pp1707-1716 (SCI)	Ping-Chiang Lyu
2010	Wey, M.T., Lyu, P.C. and Kan, L.S. ,2010,Thermodynamic and Kinetic Studies of a Stable Imperfect DNA Triplex by Spectroscopic and Calorimetric Methods,Journal of the Chinese Chemical Society,57,3B,pp496-504 (SCI)	Ping-Chiang Lyu
2010	Tseng, H.C., Lyu, P.C. and Lin, W.C.,2010,Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain,BMC Cell Biology,11,pp48- (SCI)	Ping-Chiang Lyu
2010	Pan, T.L., Hung, Y.C., Wang, P.W., Chen, S.T., Hsu, T.K., Sintupisut, N., Cheng, C.S. and Lyu, P.C.,2010,Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells,Proteomics,10,5,pp914-929 (SCI)	Ping-Chiang Lyu
2010	Lee, T.S., Pan, C.C., Peng, C.C., Kou, Y.R., Chen, C.Y., Ching, L.C., Tsai, T.H., Chen, S.F., Lyu, P.C. and Shyue, S.K,2010,Anti-Atherogenic Effect of Berberine on LXR alpha-ABCA1-Dependent Cholesterol Efflux in Macrophages,Journal of Cellular Biochemistry,111,1,pp104-110 (SCI)	Ping-Chiang Lyu
2010	Huang, P.J., Liu, Y.C., Lee, C.C., Lin, W.C., Gan, R.R.C., Lyu, P.C.* and Tang, P. ,2010,DSAP: deep-sequencing small RNA analysis pipeline,Nucleic Acids Research,38,S2,ppW385-W391 (SCI)	Ping-Chiang Lyu
2010	Huang, H. L., Hsing, H.W., Lai, T.C., Chen, Y.W., Lee, T.R., Chan, H.T., Lyu, P.C., Wu, C.L., Lu, Y.C., Lin, S.T., Lin, C.W., Lai, C.H., Chang, H.T., Chou, H.C. and Chan, H.L.,2010,Trypsin-induced proteome alteration during cell subculture in mammalian cells,Journal of Biomedical Science,17,pp36- (SCI)	Ping-Chiang Lyu
2010	Hsu, R.M., Tsai, M.H., Hsieh, Y.J., Lyu, P.C. and Yu, J.S,2010,Identification of MYO18A as a Novel Interacting Partner of the PAK2/beta PIX/GIT1 Complex and Its Potential Function in Modulating Epithelial Cell Migration,Molecular Biology of the Cell,21,2,pp287-301 (SCI)	Ping-Chiang Lyu
2010	Hsieh, Y.J., Yu, J.S. and Lyu, P.C.,2010,Characterization of Photodynamic Therapy Responses Elicited in A431 Cells Containing Intracellular Organelle-Localized Photofrin,Journal of Cellular Biochemistry ,111,4,pp821-833 (SCI)	Ping-Chiang Lyu
2010	Ho, M.R., Lou, Y.C., Wei, S.Y., Luo, S.C., Lin, W.C., Lyu, P.C. and Chen, C.P,2010,Human RegIV Protein Adopts a Typical C-Type Lectin Fold but Binds Mannan with Two Calcium-Independent Sites,Journal of Molecular Biology ,402,4,pp682-695 (SCI)	Ping-Chiang Lyu
2010	Chu, C.H., Lo, W.C., Wang, H.W., Hsu, Y.C., Hwang, J.K., Lyu, P.C., Pai, T.W. and Tang, C.Y,2010,Detection and Alignment of 3D Domain Swapping Proteins Using Angle-Distance Image-Based Secondary Structural Matching Techniques,PLOS One,5,10, (SCI)	Ping-Chiang Lyu
2010	Chou, H.C., Chen, Y.W., Lee, T.R., Wu, F.S., Chan, H.T., Lyu, P.C., Timms, J.F. and Chan, H.L.,2010,Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment,Free Radical Biology and Medicine,49,1,pp96-108 (SCI)	Ping-Chiang Lyu
2010	Chen, J.C., Uang, B.J., Lyu, P.C., Chang, J.Y., Liu, K.J., Kuo, C.C., Hsieh, H.P., Wang, H.C., Cheng, C.S., Chang, Y.H., Chang, M.D.T., Chang, W.S.W. and Lin, C.C. ,2010,Design and Synthesis of alpha-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis,Journal of Medicinal Chemistry,53,11,pp4545-4549 (SCI)	Ping-Chiang Lyu
2009	Yang, Y.F., Cheng, K.C., Tsai, P.H., Liu, C.C., Lee, T.R. and Lyu, P.C.,2009,Alanine substitutions of noncysteine residues in the cysteine-stabilized alpha beta motif,Protein Science ,18,7,pp1498-1506 (SCI)	Ping-Chiang Lyu
2009	Lo, W.C., Lee, C.Y., Lee, C.C. and Lyu, P.C.,2009,iSARST: an integrated SARST web server for rapid protein structural similarity searches,Nucleic Acids Research ,37,ppW545-W551 (SCI)	Ping-Chiang Lyu
2009	Lo, W.C., Lee, C.C., Lee, C.Y. and Lyu, P.C.,2009,CPDB: a database of circular permutation in proteins,Nucleic Acids Research,37,ppD328-D332 (SCI)	Ping-Chiang Lyu
2009	Lo, A., Chiu, Y.Y., Rodland, E.A., Lyu, P.C., Sung, T.Y. and Hsu, W.L.,2009,Predicting helix-helix interactions from residue contacts in membrane proteins,Bioinformatics,25,8,pp996-1003 (SCI)	Ping-Chiang Lyu
2009	Ku, T.H., Lu, P.Y., Chan, C.H., Wang, T.S., Lai, S.Z., Lyu, P.C. and Hsiao, N.W,2009,Predicting melting temperature directly from protein sequences,Computational Biology and Chemistry ,33,6,pp445-450 (SCI)	Ping-Chiang Lyu
2009	Chiang, Y.K., Kuo, C.C., Wu, Y.S., Chen, C.T., Coumar, M.S., Wu, J.S., Hsieh, H.P., Chang, C.Y., Jseng, H.Y., Wu, M.H., Leou, J.S., Song, J.S., Chang, J.Y., Lyu, P.C., Chao, Y.S. and Wu, S.Y,2009,Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity,Journal of Medicinal Chemistry ,52,14,pp4221-4233 (SCI)	Ping-Chiang Lyu
2009	Chen, T., Lee, T.R., Liang, W.G., Chang, W.S.W. and Lyu, P.C.,2009,Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor,Proteins-Structure Function and Bioinformatics,77,1,pp209-219 (SCI)	Ping-Chiang Lyu
2008	Yang, Y.F., Chou, M.Y., Fan, C.Y., Chen, S.F., Lyu, P.C., Liu, C.C. and Tseng, T.L,2008,The possible interaction of CDA14 and protein elongation factor 1 alpha,Biochimica Et Biophysica Acta-Proteins and Proteomics,1784,2,pp312-318 (SCI)	Ping-Chiang Lyu
2008	Lo, W.C. and Lyu, P.C.,2008,CPSARST: an efficient circular permutation search tool applied to the detection of novel protein structural relationships,Genome Biology,9,1,ppR11- (SCI)	Ping-Chiang Lyu
2008	Lo, A., Chiu, H.S., Sung, T.Y., Lyu, P.C. and Hsu, W.L,2008,Enhanced membrane protein topology prediction using a hierarchical classification method and a new scoring function, Journal of Proteome Research,7,2,pp487-496 (SCI)	Ping-Chiang Lyu
2008	Liao, C.J., Chin, K.H., Lin, C.H., Tsai, P.S.F., Lyu, P.C., Young, C.C., Wang, A.H.J. and Chou, S.H.,2008,Crystal structure of DFA0005 complexed with alpha-ketoglutarate: A novel member of the ICL/PEPM superfamily from alkali-tolerant Deinococcus ficus,Proteins-Structure Function and Bioinformatics ,73,2,pp362-371 (SCI)	Ping-Chiang Lyu
2008	Lai, Y.T., Cheng, C.S., Liu, Y.N., Liu, Y.J. and Lyu, P.C.,2008,Effects of ligand binding on the dynamics of rice nonspecific lipid transfer protein 1: A model from molecular simulations,Proteins-Structure Function and Bioinformatics,72,4,pp1189-1198 (SCI)	Ping-Chiang Lyu
2008	Hsiao, C.J., Li, T.K., Chan, Y.L., Hsin, L.W., Liao, C.H., Lee, C.H., Lyu, P.C. and Guh, J.H.,2008,WRC-213, an L-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers,Biochemical Pharmacology,75,4,pp847-856 (SCI)	Ping-Chiang Lyu
2008	Hsiao, C.J., Ho, Y.F., Hsu, J., Chang, W.L., Chen, Y.C., Shen, Y.C., Lyu, P.C. and Guh, J.H.,2008,Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress,Naunyn-Schmiedebergs Archives of Pharmacology,378,6,pp599-608 (SCI)	Ping-Chiang Lyu
2008	Cheng, C.S., Chen, M.N., Lai, Y.T., Chen, T., Lin, K.F., Liu, Y.J. and Lyu, P.C,2008,Mutagenesis study of rice nonspecific lipid transfer protein 2 reveals residues that contribute to structure and ligand binding,Proteins-Structure Function and Bioinformatics,70,3,pp695-706 (SCI)	Ping-Chiang Lyu
2007	Lin, S.C., Chueh, S.C., Hsiao, C.J., Li, T.K., Chen, T.H., Liao, C.H., Lyu, P.C., and Guh, J.H,2007,Prazosin displays anticancer activity against human prostate cancers: Targeting DNA and cell cycle,Neoplasia,9,10,pp830-839 (SCI)	Ping-Chiang Lyu
2007	Lo, W.C., Huang, P.J., Chang, C.H. and Lyu, P.C,2007,Protein structural similarity search by Ramachandran codes,BMC Bioinformatics,8,pp307- (SCI)	Ping-Chiang Lyu
2007	Yang, J.T., Huang, K.J., Tung, K.Y., Hu, I.C. and Lyu, P.C,2007,A chaotic micromixer modulated by constructive vortex agitation, Journal of Micromechanics and Microengineering,17,10,pp2084-2092 (SCI)	Ping-Chiang Lyu
2007	Lin, K.F., Lee, T.R., Tsai, P.H., Hsu, M.P., Chen, C.S. and Lyu, P.C,2007,Structure-based protein engineering for alpha-amylase inhibitory activity of plant defensin, Proteins-Structure Function and Bioinformatics,68,2,pp530-540 (SCI)	Ping-Chiang Lyu
2007	Liu, Y.N., Lai, Y.T., Chou, W.I., Chang, M.D.T. and Lyu, P.C,2007,Solution structure of family 21 carbohydrate-binding module from Rhizopus oryzae glucoamylase,Biochemical Journal,403,pp21-30 (SCI)	Ping-Chiang Lyu
2007	Wang, L.L., Yang, J.T. and Lyu, P.C,2007,An overlapping crisscross micromixer,Chemical Engineering Science,62,3,pp711-720 (SCI)	Ping-Chiang Lyu
2007	Ruan, S.K., Chin, K.H., Shr, H.L., Lyu, P.C., Wang, A.H.J. and Chou, S.H,2007,Preliminary X-ray analysis of XC5848, a hypothetical ORFan protein with an Sm-like motif from Xanthomonas campestris,Acta Crystallographica Section F-Structural Biology and Crystallization Communications,63,pp30-33 (SCI)	Ping-Chiang Lyu
2007	Yang, J.T., Chen, C.K., Hu, I.C. and Lyu, P.C,2007,Design of a self-flapping microfluidic oscillator and diagnosis with fluorescence methods,Journal of Microelectromechanical Systems,16,4,pp826-835 (SCI)	Ping-Chiang Lyu
2006	Lin, C.W., Lin, K.H., Lyu, P.C., and Chen, W.J,2006,apanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper,Virus Research,116,1-2,pp106-113 (SCI)	Ping-Chiang Lyu
2006	Mahindroo, N., Wang, C.C., Liao, C.C., Huang, C.F., Lu, I.L., Lien, T.W., Peng, Y.H., Huang, W.J., Lin, Y.T., Hsu, M.C., Lyu, P.C., Chao, Y.S., Wu, S.Y., and Hsieh, H.P,2006,Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists：Design, synthesis, structural biology, and molecular docking studies,Journal of Medicinal Chemistry,49,3,pp1212-1216 (SCI)	Ping-Chiang Lyu
2006	Ho, M.R., Lou, Y.C., Lin, W.C., Lyu, P.C., Huang, W.N. and Chen, C,2006,Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation,Journal of Biological Chemistry ,281,44,pp33566-33576 (SCI)	Ping-Chiang Lyu
2006	Mahindroo, N., Peng, Y.H., Lin, C.H., Tan, U.K., Prakash, E., Lien, T.W., Lu, I.L., Lee, H.J., Hsu, J.T.A., Chen, X., Liao, C.C., Lyu, P.C., Chao, Y.S., Wu, S.Y. and Hsieh, H.P,2006,Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists,Journal of Medicinal Chemistry,49,21,pp6421-6424 (SCI)	Ping-Chiang Lyu
2006	Hu, I.C., Lee, T.R., Lin, H.F., Chiueh, C.C., and Lyu, P.C,2006,Biosynthesis of fluorescent allophycocyanin alpha-subunits by autocatalytic bilin attachment,Biochemistry ,45,23,pp7092-7099 (SCI)	Ping-Chiang Lyu
2006	Liu, Y.J., Cheng, C.S., Lai, S.M., Hsu, M.P., Chen, C.S., and Lyu, P.C,2006,Solution structure of the plant defensin VrD1 from mung bean and its possible role in insecticidal activity against bruchids,Proteins-Structure Function and Bioinformatics,63,4,pp777-786 (SCI)	Ping-Chiang Lyu
2006	Tsai, J.Y., Chen, B.T., Cheng, H.C., Chen, H.C., Hsaio, N.W., Lyu, P.C., and Sun, Y.J,2006,Crystal structure of HP02429, a hypothetical protein from Helicobaccter pylori wrath a novel fold,Proteins-Structure Function and Bioinformatics,62,4,pp1138-1143 (SCI)	Ping-Chiang Lyu
2006	Lo, W.T., Chin, K.H., Shr, H.L., Gao, F.P., Lyu, P.C., Wang, A.H.J. and Chou, S.H,2006,Crystallization and preliminary X-ray analysis of XC1015, a histidine triad-like protein from Xanthomonas campestris,Acta Crystallographica Section F-Structural Biology and Crystallization Communications,62,pp1263-1265 (SCI)	Ping-Chiang Lyu
2006	Lin, C.H., Chin, K.H., Gao, F.P., Lyu, P.C., Shr, H.L., Wang, A.H.J. and Chou, S.H,2006,Cloning, crystallization and preliminary X-ray studies of XC2981 from Xanthomonas campestris, a putative CutA1 protein involved in copper-ion homeostasis,Acta Crystallographica Section F-Structural Biology and Crystallization Communications,62,pp1113-1115 (SCI)	Ping-Chiang Lyu
2006	Tsai, Y.D., Chin, K.H., Shr, H.L., Gao, F.P., Lyu, P.C., Wang, A.H.J. and Chou, S.H.,2006,Cloning, crystallization and preliminary X-ray study of XC1258, a CN-hydrolase superfamily protein from Xanthomonas campestris,Acta Crystallographica Section F-Structural Biology and Crystallization Communications ,62,pp999-1002 (SCI)	Ping-Chiang Lyu
2006	Chio, K.C., Chin, K.H., Gao, F.P., Lyu, P.C., Shr, H.L., Wang, A.H.J. and Chou, S.H,2006,The cloning, crystallization and preliminary X-ray analysis of XC2113, a YaeQ protein from Xanthomonas campestris,Acta Crystallographica Section F-Structural Biology and Crystallization Communications,62,pp1046-1048 (SCI)	Ping-Chiang Lyu

Writing

Journal Articles

School name	Country	Department	Degree	Starting date
				1987-09 ~ 1991-05
				1985-09 ~ 1987-05
				1978-09 ~ 1982-06

Service organization/unit	Title	Department	Responsbilities	Starting date
				2011-08 ~ 2012-07
				2002-02 ~ 2011-08
				1994-08 ~ 2002-02
				1991-12 ~ 1994-06

College of Life Science, National Tsing Hua University

Writing

標準版RSs 2.x套裝

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