莊永仁的個人資料 - 清華大學生命科學院

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姓名	莊永仁
個人網站	http://myjchuang.wixsite.com/yjc-lab
職銜	教授

類別	專任師資
職稱	教授
單位別	生物資訊與結構生物研究所 / 學士班 / 醫科系
授課領域	血管生物學、功能基因體學、分子調控
研究專長	我們實驗室以[血管生物學]和[癌症]等相關疾病之轉譯研究為基礎。目前研究課題如下: 1. 心臟與其他重要器官創傷後之修復與再生 2. 精準癌症治療-複合藥物及療法的選擇 3. 硼中子捕獲治療(BNCT)作用機制 4. 以斑馬魚為人類疾病研究與藥物篩檢平台

期刊論文一覽
年度	著作	著作人
2018	Huang HW, Lin YHm Lin MH, Haung YR, Chou CH, Hong HC, Wang MR, Tseng YT, Lia PC, Chung MC, Ma YJ, Wu SC, Chuang YJ, Wang HD, Wang YM, Huang HD, Lu TT, Liaw WF,2018,Extension of C. elegans lifespan using the ·NO-delivery dinitrosyl iron complexes,Journal of Biological Inorganic Chemistry, (SCI)	莊永仁
2018	Chang Z, Chen PY, Chuang YJ, Akhtar R.,2018,Zebrafish as a model to study bone maturation: nanoscale structural and mechanical characterization of age-related changes in the zebrafish vertebral column,Journal of the Mechanical Behavior of Biomedical Materials,3,84,pp54-63 (SCI)	莊永仁
2018	Chang SJ, Liao EC, Yeo HY, Kuo WH, Chen HY, Tsai YT, Wei YS, Chen YJ, Wang YS, Li JM, Shih CC, Chan CH, Lai ZY, Chou HC, Chuang YJ* and Chan HL,2018,Proteomic Investigating the Cooperative Lethal Effect of EGFR and MDM2 Inhibitors on Ovarian Carcinoma,Archives of Biochemistry and Biophysics*, (SCI)	莊永仁
2018	Liu FY, Hsu TC, Choong P, Lin MH, Chuang YJ, Chen BS, Lin C.,2018,Uncovering the regeneration strategies of zebrafish organs: a comprehensive systems biology study on heart, cerebellum, fin, and retina regeneration., BMC systems biology,12,Suppl 2,pp29- (SCI)	莊永仁
2017	Tzu-Wei Wang, Kai-Chieh Chang,a Liang-Hsin Chen, Shih-Yung Liao,Chia-Wei Yeh and Yung-Jen Chuang,2017,Effects of an injectable functionalized selfassembling nanopeptide hydrogel on angiogenesis and neurogenesis for regeneration of the central nervous system,Nanoscale,9,pp16281-16292 (SCI)	莊永仁
2017	Bai YC, Hsia YC, Lin YT, Chen KH, Chou FI, Yang CM, Chuang YJ,2017,Effect of tumor conditions on selective uptake of boric acid in human hepatoma HepG2 cells,Anticancer Research, (SCI)	莊永仁
2017	Chi-Hwa Yang, Yu-Jung Yeh, Jiz-Yuh Wang, Ya-Wen Liu, Yen-Lin Chen, Hui-Wen Cheng, Chun-Mei Cheng, Yung-Jen Chuang, Chiou-Hwa Yuh, and Yi-Rong Chen,2017,NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish,Scientific Reports, (SCI)	莊永仁
2017	Wu HC, Lyau JB, Lin MS, Chuang YJ, Chen H ,2017,Multilayer Microfluidic Systems with Iridium-Tin-Oxide MicroelectrodMultilayer Microfluidic Systems with Iridium-Tin-Oxide Microelectrodes for Studying Biological Cells,Journal of Micromechanics and Microengineering, (SCI)	莊永仁
2017	Lai ZY, Yeo HY, Chen YT, Chang KM, Chen TC, Chuang YJ, Chang SJ.,2017,PI3K inhibitor enhances the cytotoxic response to etoposide and cisplatin in a newly established neuroendocrine cervical carcinoma cell line,Oncotarget, (SCI)	莊永仁
2017	Lee IJ, Yang YC, Hsu JW, Chang WT, Chuang YJ, Liau I,2017,Zebrafish model of photochemical thrombosis for translational research and thrombolytic screening in vivo,Journal of Biophotonics,4,pp494-502 (SCI)	莊永仁
2016	Liu LY, Lin MH, Lai ZY, Jiang JP, Huang YC, Jao LE, Chuang YJ,2016,Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway,Journal of Biomedical Science,23,1,pp59- (SCI)	莊永仁
2016	You MS, Jiang YJ, Yuh CH, Wang CM, Tang CH, Chuang YJ, Lin BH, Wu JL, Hwang SP,2016,A Sketch of the Taiwan Zebrafish Core Facility,Zebrafish,Suppl 1,pp24-29 (SCI)	莊永仁
2016	Alice Ian Pan, Min-Hsuan Lin, Hui-Wen Chung, Hsin Chen, Shih-Rung Yeh, Yung-Jen Chuang, Yen-Chung Chang and Tri-Rung Yew ,2016,Direct-growth carbon nanotubes on 3D structural microelectrodes for electrophysiological recordings,Analyst, (SCI)	莊永仁
2015	Chen CJ, Tsai KC, Kuo PH, Chang PL, Wang WC, Chuang YJ, Chang MDT,2015,A Heparan Sulfate-Binding Cell Penetrating Peptide for Tumor Targeting and Migration Inhibition,Biomed Research International.,2015, (SCI)	莊永仁
2014	Lin C, Lin CN, Wang YC, Liu FY, Chien YW, Chuang YJ, Lan CY, Hsieh WP, Chen BS,2014,Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection,BMC Syst Biol.,8,S5,ppS6- (SCI)	莊永仁
2014	Lin C, Lin CN, Wang YC, Liu FY, Chuang YJ, Lan CY, Hsieh WP, Chen BS,2014,The role of TGF-ß signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach,BMC Syst Biol.,8,1,pp116- (SCI)	莊永仁
2014	Lin LH, Chang SJ, Hu RY, Lin MW, Lin ST, Huang SH, Lyu PC, Chou HC, Lai ZY, Chuang YJ and Chan HL,2014,Biomarker Discovery for Neuroendocrine Cervical Cancer,Electrophoresis,35,14,pp2039-2045 (SCI)	莊永仁
2014	Wang YC, Tsai IC, Lin C, Hsieh WP, Lan CY, Chuang YJ, Chen BS,2014,Essential Functional Modules for Pathogenic and Defensive Mechanisms in Candida albicans Infections,Biomed Research International.,2014,136130, (SCI)	莊永仁
2014	2014,On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio,PLoS One.,9,6,ppe97902- (SCI)	莊永仁
2013	Chen MH, Jan YH, Chang PM, Chuang YJ, Yeh YC, Lei HJ, Hsiao M, Huang SF, Huang CY, Chau GY,2013,Expression of GOLM1 Correlates with Prognosis in Human Hepatocellular Carcinoma,Ann Surg Oncol. ,Suppl 3,ppS616-624 (SCI)	莊永仁
2013	Chen CH, Ho YC, Ho HH, Chang IC, Kirsch KH, Chuang YJ, Layne MD, Yet SF,2013,Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration,Cardiovasc Res,100,3,pp461-471 (SCI)	莊永仁
2013	Lin CC, Chang TC, Lai CH, Chien CW, Liang CF, Adak AK, Chuang YJ, Chen YJ,2013,Synthesis and Evaluation of a Photoactive Probe with a Multivalent Carbohydrate for Capturing Carbohydrate-Lectin Interactions,Bioconjug Chem,24,11,pp1895-1906 (SCI)	莊永仁
2013	11. Lai CH, Lai NC, Chuang YJ, Chou FI, Yang CM, Lin CC,2013,Trivalent galactosyl-functionalized mesoporous silica nanoparticles as a target-specific delivery system for boron neutron capture therapy,Nanoscale,5,19,pp9412-9418 (SCI)	莊永仁
2013	Lai CH, Chang TC, Chuang YJ, Tzou DL, Lin CC,2013,Stepwise Orthogonal Click Chemistry toward Fabrication of Paclitaxel/Galactose Functionalized Fluorescent Nanoparticles for HepG2 cell Targeting and Delivery,Bioconjug Chem,24,10,pp1698-1709 (SCI)	莊永仁
2013	Chen YY, Chao CC, Lui FC, Hsu PC, Chen HF, Peng CH, Chuang YJ, Hsieh WP, Wang DS.,2013,Dynamic transcript profiling of Candida albicans infection in zebrafish: a pathogen-host interaction study.,PLoS One,8,9,ppe72483- (SCI)	莊永仁
2013	Kuo ZY, Chuang YJ, Chao CC, Liu FC, Lan CY and Chen BS,2013,Identification of infection-related and defense-related genes via a dynamic host-pathogen interaction network using a C. Albicans - zebrafish infection model,Journal of Innate Immunity,5,2,pp137-152 (SCI)	莊永仁
2013	Yeh CT, Su CL, Huang CY, Lin JK, Lee WH, Chang PM, Kuo YL, Liu YW, Wang LS, Wu CH, Shieh YS, Jan YH, Chuang YJ, Hsiao M, Wu AT,2013,A preclinical evaluation of antimycin a as a potential antilung cancer stem cell agent,Evid Based Complement Alternat Med.,	莊永仁
2013	12. Wang YC, Lin C, Chuang MT, Hsieh WP, Lan CY, Chuang YJ, Chen BS,2013, Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study.,BMC Syst Biol.,7,79, (SCI)	莊永仁
2013	Hsu PC, Chao CC, Yang CY, Ye YL, Liu FC, Chuang YJ, Lan CY,2013,Diverse Hap43-independent functions of the Candida albicans CCAAT-binding complex,Eukaryot Cell.,12,6,pp804-815 (SCI)	莊永仁
2013	Huang WC, Yang CC, Chen IH, Liu YM, Chang SJ, Chuang YJ,2013,Treatment of Glucocorticoids Inhibited Early Immune Responses and Impaired Cardiac Repair in Adult Zebrafish,PLoS One,8,6,ppe66613- (SCI)	莊永仁
2013	Chen IH, Wang HH, Hsieh YS, Yeh HI, Chuang YJ,2013,PRSS23 is essential for the Snail-dependent endothelial to mesenchymal transition during valvulogenesis in zebrafish,Cardiovascular Research,97,3,pp443-453 (SCI)	莊永仁
2012	Yeh YT, Lee CI, Lim SH, Chen LJ, Wang WL, Chuang YJ, Chiu JJ,2012,Convergence of physical and chemical signaling in the modulation of vascular smooth muscle cell cycle and proliferation by fibrillar collagen-regulated P66Shc,Biomaterials,33,28,pp6728-6738 (SCI)	莊永仁
2012	Jan YH, Tsai HY, Yang CJ, Huang MS, Yang YF, Lai TC, Lee CH, Jeng YM, Huang CY, Su JL, Chuang YJ, Hsiao M.,2012,Adenylate kinase 4 promotes lung cancer metastasis through the downregulation of ATF3 and correlates with poor clinical outcome,Cancer Res,72,19,pp5119-5129 (SCI)	莊永仁
2012	Chan HS, Chang SJ, Wang TY, Ko HJ, Lin YC, Lin KT, Chang KM, Chuang YJ,2012,Serine protease PRSS23 is upregulated by estrogen receptor α and associated with proliferation of breast cancer cells,PLoS One,7,1,ppe30397- (SCI)	莊永仁
2012	22. Chen FF, Lin WH, Lin SC, Kuo JH, Chu HY, Huang WC, Chuang YJ, Lee SC, Sue SC,2012,Significance of heparin binding to basic residues in homologous to amino terminus domain of hepatoma-derived growth factor and related proteins,Glycobiology,22,5,pp649-661	莊永仁
2012	23. Lai CH, Lin YC, Chou FI, Liang CF, Lin EW, Chuang YJ, Lin CC.,2012,Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy., Chem Commun （Camb）,48,4,pp612-614 (SCI)	莊永仁
2011	Chen BS, Lin YP, Chuang YJ,2011,Robust H-infinity Observer-based Tracking Control of Stochastic Immune Systems under Environmental Disturbances and Measurement Noises,Asian J Control.,13,5,pp667-690 (SCI)	莊永仁
2011	Peng CH, Liao CT, Peng SC, Chen YJ, Cheng AJ, Juang JL, Tsai CY, Chen TC, Chuang YJ, Tang CY, Hsieh WP, Yen TC,2011,A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma,PLoS One.,6,8,ppe23452- (SCI)	莊永仁
2011	Chen BS, Chang CH, Chuang YJ,2011,Robust control of immune systems under noises: stochastic game approach,Springer Handbooks of Computational Statistics, (Others)	莊永仁
2011	Kuo MW, Wang CH, Wu HC, Chang SJ, Chuang YJ,2011,Soluble THSD7A Is an N-Glycoprotein That Promotes Endothelial Cell Migration and Tube Formation in Angiogenesis,PLoS One,6,12,ppe29000- (SCI)	莊永仁
2011	Wang CH, Chen IH, Kuo MW, Su PT, Lai ZY, Wang CH, Huang WC, Hoffman J, Kuo CJ, You MS, Chuang YJ,2011,Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development,Dev Dyn.,240,6,pp1412-1421 (SCI)	莊永仁
2011	Luo WY, Shih YS, Lo WH, Chen HR, Wang SC, Wang CH, Chien CH, Chiang CS, Chuang YJ, Hu YC,2011,Baculovirus vectors for antiangiogenesis-based cancer gene therapy,Cancer Gene Ther., (SCI)	莊永仁
2011	Lin, R.Z., Wang, T.P., Hung, R.J., Chuang, Y.J., Chien, C.C. and Chang, H.Y. ,2011,Tumor-induced Endothelial Cell Apoptosis: Roles of NAD(P)H Oxidase-Derived Reactive Oxygen Species,Journal of Cellular Physiolog,226,7,pp1750-1762 (SCI)	莊永仁
2011	Kang, C.C., Chuang, Y.J., Tung, K.C., Cho, C.C., Tang, C.Y., Peng, S.C. and Wong, D.S.,2011,A Genetic Algorithm-based Boolean Delay Model of Intracellular Signal Transduction in Inflammation,BMC Bioinformatics,12,S1,ppS17- (SCI)	莊永仁
2010	Yang, S.K., Wang, Y.C., Chao, C.C., Chuang, Y.J., Lan, C.Y. and Chen, B.S. ,2010,Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNF alpha-induced inflammatory responses,BMC Medical Genomics,03,pp19- (SCI)	莊永仁
2010	Wang, C.H., Su, P.T., Du, X.Y., Kuo, M.W., Lin, C.Y., Yang, C.C., Chan, H.S., Chang, S.J., Kuo, C., Seo, K., Leung, L.L. and Chuang, Y.J.,2010,Thrombospondin Type I Domain Containing 7A (THSD7A) Mediates Endothelial Cell Migration and Tube Formation,Journal of Cellular Physiology,222,3,pp685-694 (SCI)	莊永仁
2010	Peng, S.C., Wong, D.S.H., Tung, K.C., Chen, Y.Y., Chao, C.C., Peng, C.H., Chuang, Y.J.* and Tang, C.Y. ,2010,Computing modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-kappa B signaling-induced gene expression responses in inflammation,BMC Bioinformatics ,11,pp308- (SCI)	莊永仁
2010	Lai, C.H., Lin, C.Y., Wu, H.T., Chan, H.S., Chuang, Y.J., Chen, C.T. and Lin, C.C. ,2010,Galactose Encapsulated Multifunctional Nanoparticle for HepG2 Cell Internalization, Advanced Functional Materials,20,22,pp3948-3958 (SCI)	莊永仁
2010	Huang, W.C., Hsieh, Y.S., Chen, I.H., Wang, C.H., Chang, H.W., Yang, C.C., Ku, T.H., Yeh, S.R. and Chuang, Y.J.,2010,Combined Use of MS-222 (Tricaine) and Isoflurane Extends Anesthesia Time and Minimizes Cardiac Rhythm Side Effects in Adult Zebrafish,Zebrafish,7,3,pp297-304 (SCI)	莊永仁
2010	Chao, C.C., Hsu, P.C., Jen, C.F., Chen, I.H., Wang, C.H., Chan, H.C., Tsai, P.W., Tung, K.C., Wang, C.H., Lan, C.Y., Chuang, Y.J.,2010,Zebrafish as a Model Host for Candida albicans Infection,Infection and Immunity ,78,6,pp2512-2521 (SCI)	莊永仁
2009	Chen, G.Y., Shiah, H.C., Su, H.J., Chen, C.Y., Chuang, Y.J., Lo, W.H., Huang, J.L., Chuang, C.K., Hwang, S.M. and Hu, Y.C. ,2009,Baculovirus Transduction of Mesenchymal Stem Cells Triggers the Toll-Like Receptor 3 Pathway,Journal of Virology,83,20,pp10548-10556 (SCI)	莊永仁
2008	Chen, M.L., Adak, A.K., Yeh, N.C., Yang, W.B., Chuang, Y.J., Wong, C.H., Hwang, K.C., Hwu, J.R.R., Hsieh, S.L. and Lin, C.C. ,2008,Fabrication of an Oriented Fc-Fused Lectin Microarray through Boronate Formation,Angewandte Chemie-International Edition,47,45,pp8627-8630 (SCI)	莊永仁
2008	Chen, B.S., Yang, S.K., Lan, C.Y. and Chuang, Y.J.,2008,A systems biology approach to construct the gene regulatory network of systemic inflammation via microarray and databases mining,BMC Medical Genomics ,1,pp46- (SCI)	莊永仁
2008	Chen, B.S., Chang, C.H. and Chuang, Y.J.,2008,Robust model matching control of immune systems under environmental disturbances: Dynamic game approach,Journal of Theoretical Biology ,253,4,pp824-837 (SCI)	莊永仁
2006	Zhang, W.Q., Chuang, Y.J., Jin, T.Q., Swanson, R., Xiong, Y., Leung, L. and Olson, S.T.,2006,Antiangiogenic antithrombin induces global changes in the gene expression profile of endothelial cells,Cancer Research ,66,10,pp5047-5055 (SCI)	莊永仁

專利一覽
年度	專利類別	專利名稱	西元年月	專利人
2017	其他	具細胞親和力與電容耦合性之立體電極及包含其之生物探針	2017-02-00	莊永仁 / 潘怡安、游萃蓉、陳新、莊永仁
2014	其他	Devices and methods for tracking moving objects （美國專利）	2014-12-00	莊永仁 / 黃詩音,陳永昌,莊永仁
2014	其他	追蹤移動物件之裝置與方法（中華民國專利）	2014-11-00	莊永仁 / 黃詩音,陳永昌,莊永仁
2014	其他	Transparent zebrafish and preparation method thereof （美國專利）	2014-04-00	莊永仁 / 莊永仁,黃威彰

校內榮譽一覽
得獎年度	獎項名稱	頒獎單位
103	傑出教學獎	國立清華大學
100	教師教學績優獎	國立清華大學生命科學院
99	教師教學績優獎	國立清華大學生命科學院
96	傑出教學獎	國立清華大學

學歷一覽
學校名稱	國別	系所	學位	起迄年月
伊利諾大學芝加哥分校	美國	生物工程系	博士	1994年09月 ~ 2000年06月
國立清華大學	中華民國	化學工程系	學士	1985年09月 ~ 1989年06月

經歷一覽
服務機關	職稱	部門/系所	擔任職務	起迄年月
國立清華大學	系主任	醫學科學系	綜理學系各項業務	2014年08月 ~ 2016年08月
國立清華大學	主任	秘書處校友服務中心	綜理中心各項業務	2014年02月 ~ 2014年07月
國立清華大學	教授	醫學科學系暨生物資訊與結構生物研究所		2013年08月 ~
國立清華大學	副教授	醫學科學系暨生物資訊與結構生物研究所		2010年08月 ~ 2013年07月
國立清華大學	助理教授	生命科學系暨生物資訊與結構生物研究所		2004年08月 ~ 2010年07月
美國史丹福大學	博士後研究員	醫學系血液科		2000年09月 ~ 2004年05月

授課課程

必修
1. 生命科學一　
2. 人體生理與解剖學　
3. 轉譯醫學　
選修
1. 血管生物學特論二　
2. 血管生物學特論一

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