Linyi ChenPersonal data of - College of Life Science, National Tsing Hua University

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Name	Linyi Chen
Personal website	https://nthulclab.wixsite.com/lclab

Category	Full-Time
Title	Professor
單位別	Institute of Molecular Medicine / Institute of Systems Neuroscience / Interdisciplinary Program of Life Science / Department of Medical Science
Discipline	Cell and Molecular Biology, Signal Transduction, Mechanism of Cell Differentiation
Research expertise	Cell and Molecular Biology, Signal Transduction, Mechanism of Cell Differentiation
Labs	Cell Biology Experiments, Cell Culture Room /

Recent Publications
Year	Publication	Author
2020	Yen-Chi Tsao, Yu-Jung Chang, Chun-Hsien Wang and Linyi Chen,2020,Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone,International Journal of Molecular Sciences*,21,pp4378- (SCI)	Linyi Chen
2020	Chu-Yuan Chang, Jui-Hung Hung, Liang-Wei Huang, Joye Li, Ka Shing Fung, Cheng-Fu Kao and Linyi Chen,2020,Epigenetic Regulation of WNT3A Enhancer duringRegeneration of Injured Cortical Neurons,International Journal of Molecular Sciences*,21,pp1891- (SCI)	Linyi Chen
2020	Yen-Ling Lian, Kuan-Wei Chen, Yu-Ting Chou, Ting-Ling Ke, Bi-Chang Chen, Yu-Chun Lin, and Linyi Chen,2020,PIP3 depletion rescues myoblast fusion defect in human rhabdomyosarcoma cells,Journal of Cell Science, (SCI)	Linyi Chen
2020	Yao-Shen Huang, Ching-Hsiang Fan, Ning Hsu, Nai-Hua Chiu, Chun-Yao Wu, Chu-Yuan Chang, Bing-Huan Wu, Shi-Rong Hong, Ya-Chu Chang, Anthony Yan-Tang Wu, Vanessa Guo, Yueh-Chen Chiang, Wei-Chia Hsu, Linyi Chen, Charles Pin-Kuang Lai, Chih-Kuang Yeh* Yu-Chun Lin. ,2020,Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein.,Nano Letters*,20,2,pp1089-1100 (SCI)	Linyi Chen
2020	Yue-Zhi Lee, Huan-Chen Guo, Guan-Hao Zhao, Cheng-Wei Yang, Hsin Yu Chang, Dr Ruey-Bing Yang, Linyi Chen and Shiow-Ju Lee.,2020,Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1alpha. ,Pharmacological Research,152,pp104581- (SCI)	Linyi Chen
2020	Chu-Yuan Chang, Min-Zong Liang, Ching-Chih Wu, Pei-Yuan Huang, Hong-I Chen, Shaw-Fang Yet, Jin-Wu Tsai, Cheng-Fu Kao* and Linyi Chen. ,2020,WNT3A promotes neuronal regeneration upon traumatic brain injury. ,International Journal of Molecular Sciences*,21,pp1463- (SCI)	Linyi Chen
2019	Chung-Pin Hsieh, Wei-Tang Chang, Linyi Chen, Hwei-Hsien Chen & Ming- Huan Chan,2019,Differential inhibitory effects of resveratrol onexcitotoxicity and synaptic plasticity: involvementof NMDA receptor subtypes,Nutritional Neuroscience, (SCI)	Linyi Chen
2019	Yi-Ju Wu, Bor-Sheng Ko, Shu-Man Liang, Yi-Jhu Lu, Yee-Jee Jan, Shih-Sheng Jiang, Song-Kun Shyue, Linyi Chen and Jun-Yang Liou,2019,ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma,Cell Death & Disease,2019,10,pp408- (SCI)	Linyi Chen
2019	Chu-Yuan Chang, Min-Zong Liang, Linyi Chen,2019,Current progress of mitochondrial transplantation that promotes neuronal regeneration,Translational Neurodegeneration*,8,pp17- (SCI)	Linyi Chen
2018	Ling Chien, Min-Zong Liang, Chu-Yuan Chang, Chan Wang and Linyi Chen,2018,Mitochondrial therapy promotes regeneration of injured hippocampal neurons,Biochim Biophys Acta-Molecular Basis of Disease*,1864,9（B）,pp3001-3012 (SCI)	Linyi Chen
2018	2018,Distinct effects of resveratrol on seizures and hyperexcitability induced by NMDA and 4-aminopyridine,Nutritional Neuroscience,12,pp1-11 (SCI)	Linyi Chen
2017	Chien-Hung Shih, Yu-Jung Chang, Wei-Chieh Huang, Te-Hsuan Jang, Hsing-Jien Kung, Wen-Ching Wang, Muh-Hwa Yang, Meng-Chin Lin, Shiu-Feng Huang Shu-Wei Chou, Emily Chang, Hsn Chiu, Tien-Yu Shieh, Yu-Jen Chen, Lu-Hai Wang, Linyi Chen,2017,EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis,Oncogene, 36,（47）,pp6542-6554 (SCI)	Linyi Chen
2017	Kuan-Wei Chen and Linyi Chen,2017,Epigenetic Regulation of BDNF Gene during Development and Diseases,International Journal of Molecular Sciences, （Accepted）*,18,pp571- (SCI)	Linyi Chen
2017	Kuan-Wei Chen, Yu-Jung Chang, Chia-Ming Yeh, Yen-Ling Lian, Michael W. Y. Chan, Cheng-Fu Kao, Linyi Chen,2017,SH2B1 modulates chromatin state and MyoD occupancy to enhance expressions of myogenic genes,Biochimica et Biophysica Acta-Gene Regulatory Mechanisms*,1860,2,pp270-281 (SCI)	Linyi Chen
2016	Ya-Jean Wang, Ming-Huan Chan, Linyi Chen, Sheng-Nan Wu, Hwei-Hsien Chen,2016,Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels,Journal of Biomedical Science,23,pp47- (SCI)	Linyi Chen
2016	Tim Ting-Chung Yen, Anderson Yang, Wen-Tai Chiu, Kuan-Ying Lu, Lyu-Han Wang, Hui-Chen Wang, Linyi Chen, Wen-Ching Wang, Wenya Huang, Meng-Ru Shen, Ih-Jen Su, and Lily Hui-Ching Wang,2016,Hepatitis B Virus PreS2-mutant Large Surface Antigen Modulates Store-Operated Calcium Entry and thereby Promotes Chromosome Instability,Oncotarget,7,17,pp23346-23360 (SCI)	Linyi Chen
2015	Da-Wei Yeh, Yu-Syuan Chen, Chao-Yang Lai, Yi-Ling Liu, Chih-Hao Lu, Jeng-Fan Lo, Linyi Chen, Li-Chung Hsu, Yunping Luo, Rong Xiang and Tsung-Hsien Chuang,2015,Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells,Cell Death and Differentiation,doi:10.1038/cdd.2015.147, (SCI)	Linyi Chen
2015	Szu-Ting Liu, Ling Chien, Wun-Ke Chen, Chuang-Rung Chang, Mou-Chieh Kao, Kuan-Wei Chen, I-Chou Hsiang, Yu-Jen Chen, and Linyi Chen,2015,Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons,Oncotarget*,6,31,pp30628-30639 (SCI)	Linyi Chen
2015	Kuan-Wei Chen, Yu-Jung Chang, and Linyi Chen,2015,SH2B1 orchestrates signaling events to filopodium formation during neurite outgrowth,Communicative & Integrative Biology*,8（4）, e1044189,	Linyi Chen
2015	Chien-Jen Chen, Chien-Hung Shih, Yu-Jung Chang, Shao-Jing Hong, Tian-Neng Li, Lily Hui-Ching Wang, and Linyi Chen,2015,SH2B1 and IRSp53 promote the formation of dendrites and dendritic branches,Journal of Biological Cheminstry*,290,10,pp6010-6021 (SCI)	Linyi Chen
2015	Li-Jing Chen, Li Chuang, Yi-Hsuan Huang, Jing Zhou, Seh Hong Lim, Chih-I Lee, Wei-Wen Lin, Ting-Er Lin, Wei-Li Wang, Linyi Chen, Shu Chien, and Jeng-Jiann Chiu,2015,MicroRNA Mediation of Endothelial Inflammatory Response to Smooth Muscle Cells and its Inhibition by Atheroprotective Shear Stress,Circulation Research,116,pp1157-1169 (SCI)	Linyi Chen
2014	Shao-Jing Hong, Szu-Ting Liu, Chien-Jen Chen and Linyi Chen,2014,SH2B1 increases the numbers of IRSp53-induced filopodia,Biochimica et Biophysica Acta-General Subjects,1840,pp3335-3344 (SCI)	Linyi Chen
2014	Rajesh Raju, Shyam Mohan Palapetta, Varot K. Sandhya, Apeksha Sahu, Abbas Alipoor, Lavanya Balakrishnan, Jayshree Advani, Bijesh George, K. Ramachandra Kini, Geetha N. Prashanth, H. S. Prakash, T. S. Keshava Prasad, Yu-Jung Chang, Linyi Chen, Akhilesh Pandey, H. C. Harsha. ,2014,A network map of FGF-1/FGFR signaling system.,Journal of Signal Transduction,2014,pp962962-	Linyi Chen
2014	Y-C Hsu, S-L Chen, Y-J Wang, Y-H Chen, D-Y Wang, Linyi Chen, C-H Chen, H-H Chen, and I-M Chiu.,2014,Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons.,Stem Cells Translational Medicine,3:1-10, (SCI)	Linyi Chen
2014	Meng-Ling Wu, Chung-Huang Chen, Yung-Tsang Lin, Yuan-Jyun Jheng, Yen-Chun Ho, Liang-Tung Yang, Linyi Chen, Matthew D Layne and Shaw-Fang Yet,2014,Divergent signaling pathways cooperatively regulate TGF beta induction of cysteine-rich protein 2 in vascular smooth muscle cells,Cell Communication and Signaling,12,pp22- (SCI)	Linyi Chen
2014	Yu-Jung Chang, Kuan-Wei Chen, Ching-Jen Chen, Ming-Hsing Lin, Yuh-Ju Sun, Jia-Lin Lee, Ing-Ming Chiu, and Linyi Chen,2014,SH2B1beta interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation,Molecular and Cellular Biology*,34,6,pp1003- (SCI)	Linyi Chen
2013	Chien-Hung Shih, Chien-Jen Chen, and Linyi Chen,2013,New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth,PLoS ONE*,8,11,ppe79619- (SCI)	Linyi Chen
2013	Yu-Jung Chang, Che-Ming Hsu, Michael Shiang-Cheng Lu and Linyi Chen,2013,Electrical stimulation promotes nerve growth factor-induced neurite outgrowth and signaling ,Biochimica et Biophysica Acta-General Subjects,1830,8,pp4130-4136 (SCI)	Linyi Chen
2013	Ching-Yu Lin, Chieh Huo, Li-Kuo Kuo, Richard A. Hiipakka, Richard Baker Jones, Hui-Ping Lin, Yuwen Hung, Liang-Cheng Su, Jen-Chih Tseng, Ying-Yu Kuo, Yu-Ling Wang, Yasuhisa Fukui, Yung-Hsi Kao, John M. Kokontis, Chien-Chih Yeh,Linyi Chen, Shiaw-Der Yang, Hsiao-Hui Fu, Ya-Wen Chen, Kelvin K.-C. Tsai Jang-Yang Chang, Chih-Pin Chuu,2013,Cholestane-3beta, 5alphs, 6alpha-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells,PLoS ONE*,8(6):e65734, (SCI)	Linyi Chen
2013	Yi-Wen Chen, Hsiu-Chuan Chou, Szu-Ting Lin, You-Hsuan Chen, Yu-Jung Chang, Linyi Chen, and Hong-Lin Chan,2013,Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury. articleID#364519 ,Evidence-Based Complementary and Alternative Medicine ,2013,364519, (SCI)	Linyi Chen
2012	Chia-Ling Wu, Yu-Han Chou, Yu-Jung Chang, Nan-Yuan Teng, Hsin-Ling Hsu and Linyi Chen,2012,Interplay between cell migration and neurite outgrowth determines SH2B1beta-enhanced neurite regeneration of differentiated PC12 cells (corresponding author) PLoS ONE 7(4): e34999, (SCI)	Linyi Chen
2012	Yu-Tsung Shih, Mei-Cun Wang, Hsin-Hsin Peng, Ting-Fang Chen, Linyi Chen, Jang-Yang Chang, Jeng-Jiann Chiu,2012,Modulation of chemotactic and pro-inflammatory activities of endothelial progenitor cells by hepatocellular carcinoma. ,Cell. Signal.,24,pp779-793 (SCI)	Linyi Chen
2011	Tien-Cheng Wang, Hsun Chiu, Yu-Jung Chang, Tai-Yu Hsu, Ing-Ming Chiu and Linyi Chen. ,2011,The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons. PLoS ONE, in press (corresponding author),PLoS ONE, (SCI)	Linyi Chen
2011	Wu, C.L., Shih, M.F.M., Lai, J.S.Y., Yang, H.T., Turner, G.C., Chen, L. and Chiang, A.S. ,2011,Heterotypic Gap Junctions between Two Neurons in the Drosophila Brain Are Critical for Memory,Current Biology,21,10,pp848-854 (SCI)	Linyi Chen
2011	Wang, T.C., Li, Y.H., Chen, K.W., Chen, C.J., Wu, C.L., Teng, N.Y. and Chen, L.,2011,SH2B1 beta Regulates N-Cadherin Levels, Cell-Cell Adhesion and Nerve Growth Factor-Induced Neurite Initiation. (Selected in "Highlights" of the issue),Journal of Cellular Physiology,226,8,pp2063-2074 (SCI)	Linyi Chen
2010	Ravi Kasiappan, Hung-Ju Shih, Meng-Hsun Wu, Chik On Choy, Tai-Du Lin, Linyi Chen and Hsin-Ling Hsu. ,2010,The antagonism between MCT-1 and p53 affects the tumorigenic outcomes,Molecular Cancer ,9,pp311- (SCI)	Linyi Chen
2010	Lu, W-C., Chen, C-J., Hsu, H-C., Hsin-Ling Hsu and Chen, L. ,2010,The adaptor protein SH2B1β reduces hydrogen peroxide-induced cell death in PC12 cells and hippocampal neurons,Journal of Molecular Signaling*,	Linyi Chen
2009	Lin, W-F., Chen, C-J., Chang, Y-J., Chen, S.L., Chiu, I-M and Chen, L,2009,SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway.(corresponding author),Cellular Signalling,21,pp1060-1072 (SCI)	Linyi Chen
2009	Lin, W-F., Chen, C-J., Chang, Y-J., Chiu, I-M and Chen, L.* ,2009,SH2B1b enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway,Cellular Signalling ,23,7,pp1077-1091 (SCI)	Linyi Chen
2008	Li, H., Shih, W-H., Shih, W-Y., Chen, L., Tseng, S-J., and Tang, S-C.,2008,Transfection of aqueous CdS quantum dots using polyethylenimine,Li, H., Shih, W-H., Shih, W-Y., Chen, L., Tseng, S-J., and Tang, S-C. (2008) Transfection of aqueous CdS quantum dots using polyethylenimine. Nanotechnology 19: 475101-475108.,19,pp475101-475108 (SCI)	Linyi Chen
2008	Chen, L ., Maures, T. J., Jin, H., Huo, J. S., Rabbani, S. A., Schwartz, J. and Carter-Su, C.,2008,SH2B1b (SH2-Bb) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plaminogen activator receptor and matrix metalloproteinase 3/10,Molecular Endocrinology,22,2,pp454-476 (SCI)	Linyi Chen
2004	Sipos, G., Brickner, J. H., Brace, E. J., Chen L., Rambourg, A., Kepes, F. and Fuller, R. S.,2004,Soi3/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of Trans-Golgi network transmembrane proteins,Molecular Biology of the Cell,15,7,pp3196-3209 (SCI)	Linyi Chen
2004	Chen, L., and Carter-Su, C,2004,Adaptor protein SH2-Bb undergoes nucleo-cytoplasmic shuttling: Implications for Nerve Growth Factor induction of neuronal differentiation,Molecular and Cellular Biology,24,9,pp3633-3647 (SCI)	Linyi Chen
2004	Sun, B., Chen, L., and Davis, N. G.,2004,The yeast casein kinase Yck3p is palmitoylated, then sorted to the vacuolar membrane with AP-3-dependent recognition of a YXXF adaptin sorting signal,Molecular Biology of the Cell,15,pp1397-1406 (SCI)	Linyi Chen
2004	Wang, X., Chen, L., Maures, T., Herrington, J., and Carter-Su, C.( These authors contribute equally.) ,2004,SH2-B is a positive regulator of Nerve Growth Factor-mediated activation of the Akt/Forkhead pathway in PC12 cells,Journal of Biological Chemistry,279,1,pp133-141 (SCI)	Linyi Chen
2004	2004,Wang, X., Chen, L., Maures, T., Herrington, J., and Carter-Su, C. (2004) SH2-B is a positive regulator of Nerve Growth Factor-mediated activation of the Akt/Forkhead pathway in PC12 cells. Journal of Biological Chemistry, 279(1): 133-141. ( These authors contribute equally.) , (SCI)	Linyi Chen
2004	2004,Sun, B., Chen, L., and Davis, N. G. (2004) The yeast casein kinase Yck3p is palmitoylated, then sorted to the vacuolar membrane with AP-3-dependent recognition of a YXXF adaptin sorting signal. Molecular Biology of the Cell, 15: 1397-1406. , (SCI)	Linyi Chen
2004	2004,Chen, L., and Carter-Su, C. (2004) Adaptor protein SH2-Bb undergoes nucleo-cytoplasmic shuttling: Implications for Nerve Growth Factor induction of neuronal differentiation. Molecular and Cellular Biology, 24(9): 3633-3647. , (SCI)	Linyi Chen
2004	2004,Sipos, G., Brickner, J. H., Brace, E. J., Chen L., Rambourg, A., Kepes, F. and Fuller, R. S. (2004) Soi3/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of Trans-Golgi network transmembrane proteins. Molecular Biology of the Cell, 15(7): 3196-3209. , (SCI)	Linyi Chen
2002	Roth, A.F., Feng, Y., Chen, L., and Davis, N. G.,2002,The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase,Journal of Cell Biology,159,1,pp23-28 (SCI)	Linyi Chen
2002	Chen, L. and Davis, N. G.,2002,Ubiquitin-independent entry into the yeast recycling pathway. ,Traffic,3,2,pp110-123 (SCI)	Linyi Chen
2002	2002,Chen, L. and Davis, N. G. (2002) Ubiquitin-independent entry into the yeast recycling pathway. Traffic, 3(2): 110-23. , (SCI)	Linyi Chen
2002	2002,Roth, A.F., Feng, Y., Chen, L., and Davis, N. G. (2002) The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. Journal of Cell Biology, 159(1): 23-28, (SCI)	Linyi Chen
2000	Chen, L. and Davis, N. G.,2000,Recycling of the yeast a-factor receptor. ,Journal of Cell Biology,151,3,pp731-738 (SCI)	Linyi Chen
2000	2000,Chen, L. and Davis, N. G. (2000) Recycling of the yeast a-factor receptor. Journal of Cell Biology, 151(3): 731-738. , (SCI)	Linyi Chen
1994	1994,Yang, S-C, Lin, J-G, Chiou, C-C, Chen, L-Y, Yang, J-L. (1994) Mutation specificity of 8-methoxypsoralen plus two doses of UVA irradiation in the HPRT gene in diploid human fibroblasts. Carcinogenesis, 15(2), 201-207. , (SCI)	Linyi Chen

School name	Country	Department	Degree	Starting date
				~
				1992-10 ~ 1994-04

College of Life Science, National Tsing Hua University

標準版RSs 2.x套裝

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103	Outstanding mentor award, National Tsing Hua University	National Tsing Hua University
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107	Postdoctoral Fellow Dr. Yu-Jung Chang is awarded "Miracle Award" during 15th Conference of Asia Society of Mitochondrial Research and Medicine	Asia Society of Mitochondrial Research and Medicine
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107	張筑芫 is awarded the 1st Prize International symposium of Innovative Research and Graduate Education in Biomedical Science	College of Life Science, National Tsing Hua University
106		EMBO Conference
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