Jya-Wei ChengPersonal data of - College of Life Science, National Tsing Hua University

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Name	Jya-Wei Cheng
Personal website	http://life.nthu.edu.tw/~labcjw/

Category	Full-Time
Title	Professor
單位別	Institute of Biotechnology / Interdisciplinary Program of Life Science / Department of Medical Science
Discipline	Drug Design/NMR/Structural Biology
Research expertise	Drug Design/NMR/Structural Biology

Recent Publications
Year	Publication	Author
2010	Yu, H.Y., Huang, K.C., Yip, B.S., Tu, C.H., Chen, H.L., Cheng, H.T. and Cheng, J.W.,2010,Rational design of tryptophan-rich antimicrobial peptides with enhanced antimicrobial activities and specificities,Chembiochem,11,16,pp2273-2282 (SCI)	Jya-Wei Cheng
2010	Chen, H.L., Her, S.Y. Huang, K.C., Cheng, H.T., Wu, C.W., Wu, S.C. and Cheng, J.W.,2010,Identification of a Heparin Binding Peptide From the Japanese Encephalitis Virus Envelope Protein,Biopolymers,94,3,pp331-338 (SCI)	Jya-Wei Cheng
2009	Yip, B.S., Chen, H.L., Cheng, H.T., Wu, J.M. and Cheng, J.W.,2009,Solution Structure and Model Membrane Interactions of P-113, a Clinically Active Antimicrobial Peptide Derived from Human Saliva,Journal of the Chinese Chemical Society,56,5,pp961-966 (SCI)	Jya-Wei Cheng
2009	Wu, J.M., Jan, P.S., Yu, H.C., Haung, H.Y., Fang, H.J., Chang, Y.I., Cheng, J.W. and Chen, H.M. ,2009,Structure and function of a custom anticancer peptide, CB1a,Peptides ,30,5,pp839-848 (SCI)	Jya-Wei Cheng
2009	Wang, C.W., Yip, B.S., Cheng, H.T., Wang, A.H., Chen, H.L., Cheng, J.W. and Lo, H.J. ,2009,Increased potency of a novel D-beta-naphthylalanine-substituted antimicrobial peptide against fluconazole-resistant fungal pathogens,Fems Yeast Research ,9,6,pp967-970 (SCI)	Jya-Wei Cheng
2008	Weng, K.Y., Chou, N.J. and Cheng, J.W. ,2008,Triggering vacuum capillaries for pneumatic pumping and metering liquids in point-of-care immunoassays,Lab on a Chip,8,7,pp1216-1219 (SCI)	Jya-Wei Cheng
2008	Huang, K.C., Lee, M.C., Wu, C.W., Huang, K.J., Lei, H.Y. and Cheng, J.W.,2008,Solution structure and neutralizing antibody binding studies of domain III of the dengue-2 virus envelope protein,Proteins-Structure Function and Bioinformatics,70,3,pp1116-1119 (SCI)	Jya-Wei Cheng
2008	Cheng, H.T., Huang, K.C., Yu, H.Y., Gao, K.J., Zhao, X.X., Li, F., Town, J., Gordon, J.R. and Cheng, J.W.,2008,A new protocol for high-yield purification of recombinant human CXCL8((3-72))K11R/G31P expressed in Escherichia coli,Protein Expression and Purification,61,1,pp65-72 (SCI)	Jya-Wei Cheng
2007	Wu, J.M., Wei, S.Y., Chen, H.L., Weng, K.Y., Cheng, H.T. and Cheng, J.W.,2007,Solution structure of a novel D-ss-naphthylalanine substituted peptide with potential antibacterial and antifungal activities,Biopolymers,88,5,pp738-745 (SCI)	Jya-Wei Cheng
2006	Huang, K.C., Cheng, H.T., Pai, M.T., Tzeng, S.R. and Cheng, J.W.,2006,Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase,Journal of Biomolecular NMR,36,1,pp73-78 (SCI)	Jya-Wei Cheng
2006	Wei, S.Y., Wu, J.M., Kuo, Y.Y., Chen, H.L., Yip, B.S., Tzeng, S.R. and Cheng, J.W. ,2006,Solution structure of a novel tryptophan-rich Peptide with bidirectional antimicrobial activity,Journal of Bacteriology ,188,1,pp328-334 (SCI)	Jya-Wei Cheng
2005	2005,Wu CW, Lin YT, Huang KC, Cheng JW. "1H, 15N and 13C resonance assignments of the domain III of the Dengue virus envelope protein." (2005) J Biomol NMR. 33,76. ,	Jya-Wei Cheng
2003	2003,K.P. Wu, C.W. Wu, Y.P. Tsao, T.W. Kuo, Y.C. Lou,C.W. Lin, S.C. Wu and J.W. Cheng, " Structural basis of a flavivirus recognized by its neutralizing antibody: solution structure of the domain III of the Japanese encephalitis virus envelope protein " (2003) Journal of Biological Chemistry 278, 46007-46013. ,	Jya-Wei Cheng
2003	2003,M.T. Pai, C.S. Yang, S.R. Tzeng, C. Wang and J.W. Cheng, " 1H, 15N and 13C resonance assignments of the tetratricopeptide repeat (TPR) domain of hSGT " (2003) Journal of Biomolecular NMR 26, 381-382. ,	Jya-Wei Cheng
2002	2002,M.T. Pai, K.C. Huang, S.R. Tzeng, and J.W. Cheng, "1H, 15N and 13C resonance assignments of the SH2 domain of Bruton's tyrosine kinase" (2002) Journal of Biomolecular NMR 24, 163-164. ,	Jya-Wei Cheng
2002	2002,F.D. Lung, J.Y. Tsai, S.Y. Wei, J.W. Cheng, C. Chen, P. Li, and P.P. Roller, "Novel peptide inhibitors for Grb2 SH2 domain and their detection by surface plasmon resonance" (2002) Journal of Peptide Research 60, 143-149. ,	Jya-Wei Cheng
2001	2001,M.L. Jain, Y.P. Tsao, N.L. Ho, and J.W. Cheng, "A Facile Synthesis of [N1, NH2-15N2]Adenine, [N3, NH2-15N2]Adenine and [N1, N3, NH2-15N3]Adenine" (2001) Journal of Organic Chemistry 66, 6472-6475,	Jya-Wei Cheng
2001	2001,Y.P. Tsao, L.Y. Wang, S.T. Hsu, M.L. Jain, S.H. Chou, W.C. Huang, and J.W. Cheng, "The Solution Structure of [d(CGC)r(amamam)d(TTTGCG)]2" (2001) Journal of Biomolecular NMR 21, 209-220. ,	Jya-Wei Cheng
2000	2000,S.R. Tzeng, M.T. Pai, F.T. Lung, C.W. Wu, P.P. Roller, B. Lei, C.J. Wei, S.C. Tu, S.H. Chen, W.J. Soong, and J.W. Cheng, "Stability and Peptide Binding Specificity of BTK SH2 Domain: Molecular Basis for X-Linked Agammaglobulinemia" (2000) Protein Science 9, 2377-2385. ,	Jya-Wei Cheng
2000	2000,S.T. Hsu, M.T. Chou, and J.W. Cheng, "The Solution Structure of [d(CGC)r(aaa)d(TTTGCG)]2: Hybrid Junctions Flanked by DNA Duplexes" (2000) Nucleic Acids Research 28, 1322-1331. ,	Jya-Wei Cheng
2000	2000,Y.C. Lou, I.J. Lin, M.T. Pai, and J.W. Cheng, "Solution Structure of an N-Capping Peptide from the N-terminal Leucine-Repeat Region of Hepatitis Delta Antigen" (2000) Archives of Biochemistry and Biophysics 377, 219-227. ,	Jya-Wei Cheng
2000	2000,S.R. Tzeng, Y.C. Lou, M.T. Pai, and J.W. Cheng, "Solution Structure of the BTK SH3 Domain Complexed with a Proline-Rich Peptide from p120cbl" (2000) Journal of Biomolecular NMR 16, 303-312. ,	Jya-Wei Cheng
2000	2000,S.T. Hsu, M.T. Chou, S.H. Chou, W.C. Huang, and J.W. Cheng, "Hydration of [d(CGC)r(aaa)d(TTTGCG)]2" (2000) Journal of Molecular Biology 295, 1129-1137. ,	Jya-Wei Cheng
1999	1999,Y.C. Lou, F.T. Lung, M.T. Pai, S.R. Tzeng, P.P. Roller and J.W. Cheng, "Solution Structure and Dynamics of a Nonphosphorelated Cyclic Peptide Inhibitor for the Grb2 SH2 Domain" (1999) Archives of Biochemistry and Biophysics 372, 309-314. ,	Jya-Wei Cheng
1999	1999,S.H. Chou, Y.Y. Tseng, Y.R. Chen, and J.W. Cheng, "Structural Studies of Symmetric DNA Undecamers Containing Non-Symmetrical Sheared (PuGAPu):(PyGAPy) Motifs" (1999) Journal of Biomolecular NMR 14, 157-167. ,	Jya-Wei Cheng
1999	1999,I.J. Lin, Y.C. Lou, M.T. Pai, H.N. Wu and J.W. Cheng, "Solution Structure and RNA Binding Activity of the N-terminal Leucine-Repeat Region of Hepatitis Delta Antigen" (1999) PROTEINS: Structure, Function, and Genetics 37, 121-129. ,	Jya-Wei Cheng
1998	1998,J.W. Cheng, I.J. Lin, Y.C. Lou, M.T. Pai, and H.N. Wu, "Local Helix Content and Nucleic Acid Binding Activity of the N-terminal Leucine-Repeat Region of Hepatitis Delta Antigen" (1998) Journal of Biomolecular NMR 12, 183-188. ,	Jya-Wei Cheng
1998	1998,C.C. Cheng, Y.H. Jian, C.J. Lo, and J.W. Cheng, "Design and Characterization of a Short HMG-I/DAT1 Chimeric Peptide that Binds Specifically to the Minor Groove of DNA" (1998) Journal of the Chinese Chemical Society 45, 619-624. ,	Jya-Wei Cheng
1998	1998,C.S. Lee, T.K.S. Kumar, J.W. Cheng, and C. Yu, "Main-Chain Dynamics of Cardiotoxin II from Taiwan Cobra (Naja naja atra) as Studied by Carbon-13 NMR at Natural Abundance - Delineation of the role of functionally important residues" (1998) Biochemistry 37, 155-164. ,	Jya-Wei Cheng
1997	1997,H.V. Patel, S.R. Tzeng, C.Y. Liao, S.H. Chen, and J.W. Cheng, "SH3 Domain of Bruton's Tyrosine Kinase can Bind to Proline-Rich Peptides of TH Domain of the Kinase and p120cbl" (1997) PROTEINS: Structure, Function, and Genetics 29, 545-552. ,	Jya-Wei Cheng
1996	1996,Y.J. Chen, S.C. Lin, S.R. Tzeng, H.V. Patel, P.C. Lyu, and J.W. Cheng, "Stability and Folding of the SH3 Domain of Bruton's Tyrosine Kinase" (1996) PROTEINS: Structure, Function, and Genetics 26, 465-471. ,	Jya-Wei Cheng
1996	1996,S.H. Chou, L. Zhu, Z. Gao, J.W. Cheng, and B.R. Reid, "Hairpin Loops Consisting of Single Adenine Residues Closed by Sheared AA and GG Pairs Formed by the DNA Triplets AAA and GAG: Solution Structure of the d(GTACAAAGTAC) Hairpin" (1996) Journal of Molecular Biology 264, 981-1001. ,	Jya-Wei Cheng
1996	1996,J.W. Cheng, C.C. Cheng, P.C. Lyu, S.T. Chen, and T.H. Lin, "Solution Conformation of a Peptide Corresponding to Residues 151-172 of HIV-1 Integrase using NMR and CD Spectroscopy" (1996) International Journal of Peptide & Protein Research 47, 117-122. ,	Jya-Wei Cheng
1995	1995,J.W. Cheng, C. Chen, T.H. Huang, S.H. Chou, and S.H. Chen, "Conformation of the Propeptide Domain of Factor IX" (1995) Biochimica et Biophysica Acta 1245, 227-231. ,	Jya-Wei Cheng
1994	1994,S.H. Chou, J.W. Cheng, O. Fedoroff, and B.R. Reid "DNA Sequence GCGAATGAGC Containing the Human Centromere Core Sequence GAAT Forms a Self-complementary Duplex with Sheared GA Pairs in Solution" (1994) Journal of Molecular Biology 241, 467-479. ,	Jya-Wei Cheng
1994	1994,C.A. Lepre, D.A. Pearlman, J.W. Cheng, M.T. DeCenzo, D.J. Livingston, and J.M. Moore "Solution Structure of FK506 Bound to the R42K, H87V Double Mutant of FKBP-12" (1994) Biochemistry 33, 13571-13580. ,	Jya-Wei Cheng
1994	1994,J.W. Cheng, C.A. Lepre, and J.M. Moore "15N NMR Relaxation Studies of the FK506 Binding Protein: Dynamic Effects of Ligand Binding and Implications of Calcineurin Recognition" (1994) Biochemistry 33, 4093-4100. ,	Jya-Wei Cheng
1993	1993,J.W. Cheng, C.A. Lepre, S. Chambers, J. R. Fulghum, J. A. Thomson, J.M. Moore, "15N NMR Relaxation Studies of the FK506 Binding Protein: Backbone Dynamics of the Uncomplexed Receptor" (1993) Biochemistry 32, 9000-9010. ,	Jya-Wei Cheng
1993	1993,C.A. Lepre, J.W. Cheng, J.M. Moore "Dynamics of a receptor-bound ligand by heteronuclear NMR: FK506 bound to FKBP-12" (1993) J. Am. Chem. Soc. 115, 4929-4930. ,	Jya-Wei Cheng
1992	1992,S.H. Chou, J.W. Cheng, O. Fedoroff, V. Chuprina, and B.R. Reid, "Adjacent G:A Mismatch Base Pairs Contain BII Phosphodiesters in Solution." (1992) J. Am. Chem. Soc. 114, 3114-3115. ,	Jya-Wei Cheng
1992	1992,J.W. Cheng, S.H. Chou, and B.R. Reid, "Base Pairing Geometry in GA Mismatches Depends Entirely on the Neighboring Sequence" (1992) Journal of Molecular Biology 228, 1037-1041. ,	Jya-Wei Cheng
1992	1992,S.H. Chou, J.W. Cheng, and B.R. Reid, "The solution structure of [d(ATGTGCGAATA)]2: Adjacent GA Mismatches Stabilized By Cross-Strand Base-Stacking and BII phosphate Groups." (1992) Journal of Molecular Biology 228, 138-155. ,	Jya-Wei Cheng
1992	1992,J.W. Cheng, S.H. Chou, M. Salazar, and B.R. Reid, "The solution structure of [d(GCGTATACGC)]2," (1992) Journal of Molecular Biology 228, 118-137. ,	Jya-Wei Cheng
1989	1989,J.W. Cheng, and F.T. Luo, "Palladium-Catalyzed intramolecular arylpalladation via ultrasonics," Bull. Inst. Chem, Academia Sinica 36, 9-15 (1989). ,	Jya-Wei Cheng
1988	1988,B. O'connor, Yantao Zhang, N. Eiichi, F.T. Luo, and J.W. Cheng, "Metal promoted cyclizations. 20. Palladium catalyzed cyclization of alkenyl and aryl halides containing a,b-unsaturated carbonyl groups via intramolecular carbopalladation," Tetrahedron Letters 29, 3903-3906 (1988).,	Jya-Wei Cheng
1988	1988,J.W. Cheng, and F.T. Luo, "Coupling of aryl grignard reagents by electron transfer to 2,3-dichloropropene," Tetrahedron Letters 29, 1293-1294 (1988). ,	Jya-Wei Cheng

College of Life Science, National Tsing Hua University

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