Y. K. LaiPersonal data of - College of Life Science, National Tsing Hua University

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Name	Y. K. Lai
Personal website	http://life.nthu.edu.tw/~lablyk/main.html

Category	Retired
Title	Professor
單位別	Institute of Biotechnology / The Department of Life Sciences / Interdisciplinary Program of Life Science
Discipline	Biochemistry/Genetics
Research expertise	Biochemistry/Genetics

Recent Publications
Year	Publication	Author
2011	2011,Jiang L, Lai YK, Zhang J, Wang H, Lin MC, He ML, Kung HF. 2011. Targeting S100P inhibits colon cancer growth and metastasis by lentivirus-mediated RNA interference and proteomic analysis. Mol Med. 2011 Feb 9. doi: 10.2119/molmed.2011.00008. [Epub ahead of print] [SCI], (SCI)	Y. K. Lai
2011	Lo, C.W., Lai, Y.K., Liu, Y.T., Gallo, R.L. and Huang, C. M. ,2011,Staphylococcus aureus Hijacks a Skin Commensal to Intensify Its Virulence: Immunization Targeting beta-Hemolysin and CAMP Factor,Journal of Investigative Dermatology,131,2,pp401-409 (SCI)	Y. K. Lai
2011	Huang, I.P., Sun, S.P., Cheng, S.H., Lee, C.H., Wu, C.Y., Yang, C.S., Lo, L. W. and Lai, Y.K.,2011,Enhanced Chemotherapy of Cancer Using pH-Sensitive Mesoporous Silica Nanoparticles to Antagonize P-Glycoprotein-Mediated Drug Resistance,Molecular Cancer Therapeutics ,10,5,pp761-769 (SCI)	Y. K. Lai
2011	Wu, C.Y., Huang, C.K., Chung, C.Y., Huang, I.P., Hwu, Y., Yang, C.S., Lai, Y.K., Lo, L.W. and Chiang, S.Y.,2011,Probing the binding kinetics of proinflammatory cytokine-antibody interactions using dual color fluorescence cross correlation spectroscopy,Analyst ,136,10,pp2111-2118 (SCI)	Y. K. Lai
2010	2010,Tsai JJ, Liao EC, Hsu JY, Lee WJ, Lai YK. The differences of eosinophil- and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease. J Asthma. 2010. 47(9):1040-4. [SCI], (SCI)	Y. K. Lai
2010	Tseng, F.J., Chen, Y.C., Lin, Y.L., Tsai, N.M., Lee, R.P., Chung, Y.S., Chen, C.H., Liu, Y.K., Huang, Y.S., Hwang, C.H., Lai, Y.K. and Liao, K.W. ,2010,A fusion protein with the receptor binding domain of vascular endothelial growth factor-A (VEGF-A) is an antagonist of angiogenesis in cancer treatment, Cancer Biology & Therapy,10,9,pp869-877 (SCI)	Y. K. Lai
2010	Lin, C.S., He, P.J., Hsu, W.T., Wu, M.S., Wu, C.J., Shen, H.W., Hwang, C.H., Lai, Y.K., Tsai, N.M. and Liao, K.W. ,2010,Helicobacter pylori-derived Heat shock protein 60 enhances angiogenesis via a CXCR2-mediated signaling pathway,Biochemical and Biophysical Research Communications,397,2,pp283-289 (SCI)	Y. K. Lai
2010	Chang, K.C., Lo, C.W., Fan, T.C., Chang, M.D.T., Shu, C.W., Chang, C.H., Chung, C.T., Fang, S.L., Chao, C.C., Tsai, J.J. and Lai, Y.K.* ,2010,TNF-alpha Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells,BMC Cell Biology ,11,pp6- (SCI)	Y. K. Lai
2010	Tuan, T.F., Tsai, M.L., Yeh, K.C., Huang, H.C., Chung, C.T., Huang, C.L., Han, C.H., Chen, C.P., Wang, M.H., Shen, C.C., Lai, Y.K., Lee, W.S., Hwang, L.L. and Chen, C.T.,2010,Intravenous paclitaxel against metastasis of human gastric tumors of diffuse type,Cancer Chemotherapy and Pharmacology,66,4,pp773-783 (SCI)	Y. K. Lai
2010	Ko, C.H., Tsai, C.H., Tu, J., Lee, H.Y., Ku, L.T., Kuo, P.A. and Lai, Y.K.,2010,Molecular cloning and characterization of a novel thermostable xylanase from Paenibacillus campinasensis BL11,Process Biochemistry,45,10,pp1638-1644 (SCI),(Others)	Y. K. Lai
2010	Chang, J.M., Huang, K.L., Yuan, T.T.T., Lai, Y.K. and Hung, L.M. ,2010,The Anti-hepatitis B Virus Activity of Boehmeria nivea Extract in HBV-viremia SCID Mice,Evidence-Based Complementary and Alternative Medicine,7,2,pp189-195 (SCI)	Y. K. Lai
2009	Chen, P.Y., Chang, W.S.W., Lai, Y.K. and Wu, C.W.,2009,c-Myc regulates the coordinated transcription of brain disease-related PDCD10-SERPINI1 bidirectional gene pair.,Molecular and Cellular Neuroscience,42,1,pp23-32 (SCI)	Y. K. Lai
2009	Lo, C.W., Chang, Y.S., Chao, C.C., Chang, M.D.T., Chang, K.C. and Lai, Y.K.* ,2009,Control Mechanisms of Differential Translation of Hsp90 Isoforms in 9L Rat Gliosarcoma Cells.,Journal of Cellular Biochemistry,107,3,pp418-427 (SCI)	Y. K. Lai
2009	Huang, K.L., Lai, Y.K., Lin, C.C. and Chang, J.M.,2009,Involvement of GRP78 in inhibition of HBV secretion by Boehmeria nivea extract in human HepG2 2.2.15 cells,Journal of Viral Hepatitis ,16,5,pp367-375 (SCI)	Y. K. Lai
2009	Yang, S.Y., Lan, C.B., Chen, C.H., Horng, H.E., Hong, C.Y., Yang, H.C., Lai, Y.K., Lin, Y.H. and Teng, K.S.,2009,Independency of Fe ions in hemoglobin on immunomagnetic reduction assay,Journal of Magnetism and Magnetic Materials ,321,19,pp3266-3269 (SCI)	Y. K. Lai
2009	Ma, L., Lin, C.J., Chen, J.H., Fung, C.P., Chang, F.Y., Lai, Y.K., Lin, J.C. and Siu, L.K.,2009,Widespread Dissemination of Aminoglycoside Resistance Genes armA and rmtB in Klebsiella pneumoniae Isolates in Taiwan Producing CTX-M-Type Extended-Spectrum beta-Lactamases,Antimicrobial Agents and Chemotherapy ,53,1,pp104-111 (SCI)	Y. K. Lai
2008	2011,Chang JM, Huang KL, Yuan TT, Lai YK, Hung LM. 2008. The Anti-hepatitis B Virus Activity of Boehmeria nivea Extract in HBV-viremia SCID Mice. Evid Based Complement Alternat Med. [Epub ahead of print] [SCI], (SCI)	Y. K. Lai
2008	2011,Lin, FY, Lai YK, Yu, HC, Chen, NY, Chang, CY, Lo, HC, Hsu, TH. 2008. Effects of Lycium barbarum extract on production and immunomodulatory activity of the extracellular polysaccharopeptides from submerged fermentation culture of Coriolus versicolor. Food Chemistry 110: 446-453. [SCI], (SCI)	Y. K. Lai
2008	2011,Chao CC, Sun FC, Wang CH, Lo CW, Chang YS, Chang KC, Chang MD, Lai YK*. 2008. Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells. J Cell Biochem. 104:1286-1296. [SCI], (SCI)	Y. K. Lai
2008	2011,Shu CW, Sun FC, Cho JH, Lin CC, Liu PF, Chen PY, Chang MD, Fu HW, Lai YK*. 2008. GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. J Cell Physiol. 215:627-635. [SCI], (SCI)	Y. K. Lai
2008	2011,Chang JM, Huang KL, Yuan TT, Lai YK, Hung LM. 2008. The Anti-hepatitis B Virus Activity of Boehmeria nivea Extract in HBV-viremia SCID Mice. Evid Based Complement Alternat Med. [Epub ahead of print] [SCI], (SCI)	Y. K. Lai
2008	2011,Hou ML, Huang SY, Lai YK, Lee WC. 2008. Geldanamycin augments nitric oxide production and promotes capacitation in boar spermatozoa. Anim Reprod Sci. 104:56-68. [SCI], (SCI)	Y. K. Lai
2007	2011,Huang KS, Lo WH, Chung YC, Lai YK, Chen CY, Chou ST, Hu YC. 2007. Combination of baculovirus-mediated gene delivery and packed-bed reactor for scalable production of adeno-associated virus. Hum Gene Ther. 18(11):1161-1170. [SCI], (SCI)	Y. K. Lai
2007	2011,Lin CC, Hsu JT, Huang KL, Tang HK, Shu CW, Lai YK*. 2007. Sf-Caspase-1-repressed stable cells: resistance to apoptosis and augmentation of recombinant protein production. Biotechnol Appl Biochem. 48(Pt 1):11-19. [SCI], (SCI)	Y. K. Lai
2007	2011,Yang DG, Chung YC, Lai YK, Lai CW, Liu HJ, Hu YC. 2007. Avian influenza virus hemagglutinin display on baculovirus envelope: cytoplasmic domain affects virus properties and vaccine potential. Mol Ther. 15:989-996. [SCI], (SCI)	Y. K. Lai
2007	2011,Chen CC, Tai DY, Ho P, Lai YK, Lin JJ, Mao SJ, Lin CC, Hsieh YC, Chiang HC, Dai KS. 2007. Clinical evaluation of the eBsensor hand-held blood glucose monitoring system. Clin Chim Acta. 377:170-173. [SCI], (SCI)	Y. K. Lai
2007	2011,Chang HT, Kao YL, Wu CM, Fan TC, Lai YK, Huang KL, Chang YS, Tsai JJ, Chang MD. 2007. Signal peptide of eosinophil cationic protein upregulates transforming growth factor-alpha expression in human cells. J Cell Biochem. 100:1266-1275. [SCI], (SCI)	Y. K. Lai
2007	2011,Chen PY, Chang WS, Chou RH, Lai YK, Lin SC, Chi CY, Wu CW. 2007. Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner. BMC Mol Biol. 9;8:2. [SCI], (SCI)	Y. K. Lai
2006	2011,Huang KL, Lai YK, Lin CC, Chang JM. 2006. Inhibition of hepatitis B virus production by Boehmeria nivea root extract in HepG2 2.2.15 cells. World J Gastroenterol. 12:5721-5725. [SCI], (SCI)	Y. K. Lai
2006	2011,Lai CW, Chan ZR, Yang DG, Lo WH, Lai YK, Chang MD, Hu YC. 2006. Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein. FEBS Lett. 580:3829-3834. [SCI], (SCI)	Y. K. Lai
2006	2011,Chen TC, Chen GW, Hsiung CA, Yang JY, Shih SR, Lai YK, Juang JL. 2006. Combining multiplex reverse transcription-PCR and a diagnostic microarray to detect and differentiate enterovirus 71 and coxsackievirus A16. J Clin Microbiol. 44:2212-2219., (SCI)	Y. K. Lai
2006	2011,Chang YS, Lo CW, Sun FC, Chang MD, Lai YK*. 2006. Differential expression of Hsp90 isoforms in geldanamycin-treated 9L cells. Biochem Biophys Res Commun. 344(1):37-44. [SCI], (SCI)	Y. K. Lai
2006	2011,Lin CC, Hsu JT, Huang KL, Tang HK, Lai YK*. 2006. Stable RNA interference in Spodoptera frugiperda cells by a DNA vector-based method. Biotechnol Lett. 28(4):271-277. [SCI], (SCI)	Y. K. Lai
2006	2011,Sun FC, Wei S, Li CW, Chang YS, Chao CC, Lai YK*. 2006. Localization of GRP78 to mitochondria under the unfolded protein response. Biochem J. 396:31-39. [SCI], (SCI)	Y. K. Lai
2006	2011,Chang YS, Lee LC, Sun FC, Chao CC, Fu HW, Lai YK*. 2006. Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells. J Cell Biochem. 97:156-165. [SCI], (SCI)	Y. K. Lai
2006	2011,Chen LC, Lai YK, Wu SC, Lin CC, Guo JH. 2006. Production by Clonostachy compactiuscula of a Lovastatin Esterase That Converts Lovastatin to Monacolin J. Enzyme Microbial Technol. 3:1051-1059. [SCI], (SCI)	Y. K. Lai

College of Life Science, National Tsing Hua University

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